New Review of Cancer Immunotherapy With Interleukin-2- Current Status and Future Developments
LONDON, December 15, 2016 /PRNewswire/ —
Shilpa Gupta, Neeraj Agarwal, Oncology & Hematology Review, 2016;12(2):82-8, https://doi.org/10.17925/OHR.2016.12.02.82
Published recently in Oncology & Hematology Review, the peer-reviewed journal from touchONCOLOGY, Shilpa Gupta discusses high-dose interleukin-2 (HD IL-2), which has been in clinical use in the treatment of metastatic renal cell carcinoma (mRCC) and metastatic melanoma (mM) for over 20 years, and has produced substantial, durable responses in selected patients, resulting in cures in some patients with no ongoing therapy or chronic toxicity. However, use of the drug has remained limited owing to its significant acute toxicities, and the fact that only a minority of selected patients derive a response to treatment. Recent registry data support the use of HD IL-2 as first-line therapy in mRCC and mM, producing major responses for some and thus reducing the requirement for long-term therapy. In addition, an enhanced understanding of the role of IL-2 has led to the development of new therapeutic approaches to maximize the anti-tumor response of IL-2. These strategies include combined treatment with vaccines, antibody treatments to block inhibitory pathways, or adoptive cell transfer of T cells. These data and new approaches have led to continued use of HD IL-2 and may increase the number of patients who derive benefit from this treatment.
The full peer-reviewed, open-access article is available here:
https://doi.org/10.17925/OHR.2016.12.02.82
Disclosure: Shilpa Gupta has participated in Advisory Boards and speakers’ bureau for Genentech. Neeraj Agarwal has participated in Advisory Board for Pfizer, Exelixis, Cerulean, Argo and received research funding from Pfizer. This study involves a review of the literature and did not involve any studies with human or animal subjects performed by any of the authors.
Note to the Editor
touchONCOLOGY (a division of Touch Medical Media) publishes
Oncology & Hematology Review, a peer-reviewed, open access, bi-annual journal specialising in the publication of balanced and comprehensive review articles written by leading authorities to address the most important and salient developments in the field of oncology and hematology. The aim of these reviews is to break down the high science from ‘data-rich’ primary papers and provide practical advice and opinion on how this information can help physicians in the day to day clinical setting. Practice guidelines, symposium write-ups, case reports, and original research articles are also featured to promote discussion and learning amongst physicians, clinicians, researchers and related healthcare professionals.
https://www.touchONCOLOGY.com
For inquires please contact:
Nicola Cartridge – Managing Editor
editor@touchmedicalmedia.com
T: +44-(0)207-193-3186
Providing practical opinion to support best practice for busy healthcare professionals.
LONDON, December 15, 2016 /PRNewswire/ —
Shilpa Gupta, Neeraj Agarwal, Oncology & Hematology Review, 2016;12(2):82-8, https://doi.org/10.17925/OHR.2016.12.02.82
Published recently in Oncology & Hematology Review, the peer-reviewed journal from touchONCOLOGY, Shilpa Gupta discusses high-dose interleukin-2 (HD IL-2), which has been in clinical use in the treatment of metastatic renal cell carcinoma (mRCC) and metastatic melanoma (mM) for over 20 years, and has produced substantial, durable responses in selected patients, resulting in cures in some patients with no ongoing therapy or chronic toxicity. However, use of the drug has remained limited owing to its significant acute toxicities, and the fact that only a minority of selected patients derive a response to treatment. Recent registry data support the use of HD IL-2 as first-line therapy in mRCC and mM, producing major responses for some and thus reducing the requirement for long-term therapy. In addition, an enhanced understanding of the role of IL-2 has led to the development of new therapeutic approaches to maximize the anti-tumor response of IL-2. These strategies include combined treatment with vaccines, antibody treatments to block inhibitory pathways, or adoptive cell transfer of T cells. These data and new approaches have led to continued use of HD IL-2 and may increase the number of patients who derive benefit from this treatment.
The full peer-reviewed, open-access article is available here:
https://doi.org/10.17925/OHR.2016.12.02.82
Disclosure: Shilpa Gupta has participated in Advisory Boards and speakers’ bureau for Genentech. Neeraj Agarwal has participated in Advisory Board for Pfizer, Exelixis, Cerulean, Argo and received research funding from Pfizer. This study involves a review of the literature and did not involve any studies with human or animal subjects performed by any of the authors.
Note to the Editor
touchONCOLOGY (a division of Touch Medical Media) publishes
Oncology & Hematology Review, a peer-reviewed, open access, bi-annual journal specialising in the publication of balanced and comprehensive review articles written by leading authorities to address the most important and salient developments in the field of oncology and hematology. The aim of these reviews is to break down the high science from ‘data-rich’ primary papers and provide practical advice and opinion on how this information can help physicians in the day to day clinical setting. Practice guidelines, symposium write-ups, case reports, and original research articles are also featured to promote discussion and learning amongst physicians, clinicians, researchers and related healthcare professionals.
https://www.touchONCOLOGY.com
For inquires please contact:
Nicola Cartridge – Managing Editor
editor@touchmedicalmedia.com
T: +44-(0)207-193-3186
Providing practical opinion to support best practice for busy healthcare professionals.