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4 Results Found for “ADAMTS13 protein”
The first primary microangiopathic haemolytic anaemia was identified as thrombotic thrombocytopenic purpura (TTP) by Dr Moschowitz in 1924. At that time, the classic pentad of clinical features, still used today, included fever, erythrocyte fragmentation, thrombocytopenia, kidney injury and neurologic injury.1 It ...
Classification The two basic forms of thrombotic microangiopathies, excluding disseminated intravascular coagulation (DIC), include thrombotic thrombocytopenic purpura (TTP), and hemolytic uremic syndrome (HUS). Early historic reports noted the presence of hemolytic anemia and thrombocytopenia in both disorders and suggested differentiation ...
Sickle cell disease (SCD) is a common hemolytic anemia caused by a single gene mutation in the β-subunit of hemoglobin (Hb),1 affects millions of people worldwide, and is associated with significant morbidity and mortality. An estimated 83,000 US citizens have been ...
Thrombotic thrombocytopenic pupura (TTP) is a life-threatening disease characterised by microangiopathic haemolytic anaemia, consumptive thrombocytopenia and various organ dysfunctions, such as neurological symptoms, renal damage and fever.1 In order to ensure best treatment responses, early diagnosis and appropriate intervention are ...
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