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Acute myeloid leukaemia (AML) is a heterogeneous haematologic cancer associated with clonal expansion of myeloid blasts in the bloodstream, bone marrow and other tissues. AML is associated with blasts expressing various complex molecular and cytogenetic alterations, which play an important ...
The optimal maintenance approach postautologous stem cell transplantation (ASCT) for patients with multiple myeloma is still an area of ongoing research. Lenalidomide has demonstrated clear superiority in clinical trials compared to placebo, and continuous post-transplant lenalidomide until progression is considered ...
Acute myeloid leukaemia (AML) is a heterogeneous haematological malignancy characterized by the presence of ≥20% blasts in bone marrow or peripheral blood or the presence of defined genetic abnormalities.1 In 2020, there were an estimated 21,450 new patients with AML and 11,180 AML-related deaths ...
Multiple myeloma (MM) remains largely an incurable disease with only a small percentage of patients achieving long-term remission.1Â Here, we highlight some of the major studies on MM presented at the American Society of Hematology meeting in December 2021. Monoclonal gammopathy ...
Multiple myeloma (MM) is the second most common haematological malignancy, affecting an estimated 450,600 patients worldwide, with an estimated 34,920 new diagnoses and 12,410 patient deaths in the USA in 2021.1,2Â Although established curative therapies for MM have not yet been defined, we have ...
Immunoglobulin light chain (AL) amyloidosis is the most common type of systemic amyloidosis, a spectrum of diseases induced by misfolded proteins that generate insoluble amyloid fibrils and deposits in various organs. The precursor protein in AL amyloidosis is a toxic, ...
Multiple myeloma (MM) is the second most common hematological malignancy after non-Hodgkin’s lymphoma.1 Although recent decades have seen considerable advances and improvements in clinical outcomes for patients with MM,2 MM remains incurable, with a high disease burden.3 Clonal evolution ...
Myelodysplastic syndromes (MDS) are a group of clonal myeloid neoplasms characterised by blood cytopaenia, cellular dysplasia and predisposition to the development of acute myeloid leukaemia (AML).1,2 MDS are common in older individuals, with an incidence that varies from 2–12/100,000 inhabitants/year ...
The past decade has experienced a shift in the treatment landscape for multiple myeloma (MM), with the introduction of novel agents and new combination therapies which have improved survival outcomes for patients across all disease settings.1 These advances in treatment ...
Insights into the OPTIMISMM study presented at the 23rd Congress of the European Haematology Association, 14–17 June 2018, Stockholm, Sweden The introduction of immunomodulatory agents and proteasome inhibitors (PIs) has transformed the management of multiple myeloma (MM) in recent years.1 However, relapse ...
Myelodysplastic syndrome (MDS) is a cytogenetic, epigenetic, and immunological heterogeneous group of myeloid disorders characterized by dysplastic hematopoeisis and propensity for acute myelogenous leukemia (AML) transformation.1,2 The Surveillance, Epidemiology, and End Results (SEER) Program estimates that risk factors for the ...
Chronic lymphocytic leukemia (CLL) is the most prevalent adult leukemia with an estimated 18,960 new cases diagnosed in the US in 2016.1 The past few years have witnessed major advances in the treatment of CLL with several new drugs receiving US Food ...
In myelodysplastic syndrome (MDS), iron overload (IOL) is the result of multiple red blood cell (RBC) transfusions and increased iron absorption. The cause for the latter is low hepcidin levels due to an ineffective erythropoiesis.1 Increased iron absorption contributes to ...
Epigenetics encompasses heritable changes in the pattern of gene expression mediated by mechanisms other than alterations in primary nucleotide sequence. The epigenome is an inheritable record of changes to the DNA and histone proteins, such as methylation and nucleosome remodelling ...
Treatment paradigms in multiple myeloma are undergoing rapid transformation. Deep remissions are possible in a large number of patients with new effective therapies with or without autologous stem cell transplantation (ASCT), and this improvement is seen among all categories including ...
Evolution of Knowledge in Essential Thrombocythaemia Disease Presented by: Gunnar Birgegård Division of Medical Sciences, Haematology, Uppsala University, Uppsala, Sweden Essential thrombocythaemia (ET) is a serious disease with significant morbidity and mortality and can sometimes transform to acute myeloid ...
Multiple myeloma (MM) is an incurable disease characterised by accumulation of clonal plasma cells in the bone marrow and accounts for approximately 10 % of all haematological malignancies.1 Advances in the understanding of MM, better identification of high-risk patients, and the recent ...
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