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It is with great pleasure that we present the latest edition of touchREVIEWS in Oncology & Haematology. This issue highlights the remarkable progress and innovation shaping the fields of oncology and haematology, featuring articles that delve into both emerging therapies ...
Highlights Immunotherapy, especially combinatory immunotherapy, has shown promise with prolonged survival for patients with advanced mesothelioma in the first-line setting (see the sections on ‘Systemic treatment and immunotherapy debut’ and ‘Randomized immunotherapy trials of mesothelioma’). Histology-based therapy is important to ...
Cholangiocarcinomas (CCAs) are a heterogenous group of cancers arising from the biliary epithelium. While they account for around 3% of all gastrointestinal malignancies, they are the second most common primary liver cancer.1Â CCAs tend to metastasize and have early lymph node ...
Peritoneal carcinomatosis, defined as tumor dissemination in the peritoneal cavity, is a common manifestation of gastrointestinal malignancies. However, isolated peritoneal metastases (IPM) are relatively rare, though appendiceal tumors and peritoneal mesothelioma have a propensity to involve only the peritoneum. Cytoreductive ...
Hyaluronic acid (HA) is a key component of the stroma that dominates the microenvironment of tumours of several different types of cancer especially metastatic pancreatic ductal adenocarcinoma (PDA).1 It contributes to the quite solid characteristics of these tumours, and is ...
Cancer immunotherapy has come of age and has successfully been implemented as the standard of care in a number of oncologic indications.1 Antibodies targeting cancer-associated antigens on the tumour cell, such as CD20, constituted the first wave of immunotherapies leading ...
Advances have been made in the use of genetically enhanced T cell therapy, in particular, chimeric antigen receptor (CAR) T cells. Such CAR T cells have been shown to be efficacious in erradicating a number of haematologic malignancies.1–3 CARs are ...
Progress in Diagnosis The two major symptoms in patients with peritoneal mesothelioma are abdominal pain and abdominal distention. The patient may also show constitutional symptoms, such as weight loss and fever. In women, diffuse malignant peritoneal mesothelioma (DMPM) is frequently ...
Welcome to the spring edition of Oncology and Haematology Review (US), which features articles on major aspects of oncology. In the era of targeted therapy, oncologists are faced with an ever-increasing number of therapeutic options, and there is a need ...
Prognostic factors of clinical outcomes in patients with cancer are a useful tool in the practice of medicine, especially in the fields of oncology and malignant hematology. A good prognostic factor should reflect the biology of its targeted disease, be ...
‘Epigenetics’ is a term used to describe heritable states of gene expression that are not due to changes in DNA sequence. Epigenetic phenomena have been shown to play an important role in carcinogenesis and tumor progression. Such phenomena also represent ...
Despite an unparalleled campaign over the last 10 years to increase public awareness of risk factors associated with lung cancer, carcinoma of the lung remains the leading cause of cancer-related death in the US and worldwide.1,2 Epidemiological data continue to show ...
Malignant pleural mesolthelioma (MPM) is a locally aggressive cancer that arises from the multipotential mesothelial cells of the pleura. MPM has a uniformly poor prognosis with a median survival from diagnosis of nine to 12 months.4 Limited treatment options are available ...
Lung cancer is the main cause of cancer deaths for both men and women in the US and worldwide. In the US, there were approximately 232,270 new cases diagnosed and 166,280 deaths due to this disease by the end of 2008.1 Non-small-cell cancer (...
The Rationale for Hyperthermic Intraperitoneal Chemotherapy The drug concentration attainable through an IPEC instillation approach allows the intrinsic or acquired drug resistance to be overcome, simultaneously minimising the systemic toxicity. Loco-regional drug delivery under hyperthermia offers several advantages over the ...
In addition, DMPM has been reported following radiation therapy, mica exposure, recurrent peritonitis, and administration of thorium dioxide.9–13 A great majority of patients present with abdominal pain and distension caused by the accumulation of tumors and ascitic fluid.14Without ...
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