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17 Results Found for “pancreatic neoplasms”
Pancreatic cancer (PC) is the tenth most common cancer in 2024, with 66,440 new cases and 51,570 deaths.1,2Â Globally, the prevalence varies from 10/100,000 cases in the Americas and Europe to 0.9/100,000 cases in South Central Asia and most of Africa.3Â Currently, it has the ...
To date, the cornerstone of curative treatment in early-stage gastrointestinal (GI) cancers includes surgery and sometimes radiation therapy. Depending on the stage and tumour type, these approaches are often combined with systemic neoadjuvant or adjuvant therapies. After all definitive therapy ...
Neuroendocrine neoplasms (NENs) comprise a heterogenous group of malignancies with diverse clinical behaviour determined by tumour characteristics such as grade, differentiation and primary tumour origin.1 While neuroendocrine carcinomas are poorly differentiated aggressive malignancies, well-differentiated neuroendocrine tumours (NETs) tend to be ...
Pancreatic ductal adenocarcinoma (PDA) is predicted to beat colon cancer in terms of total cancer-related deaths in the USA by this year (2020).1Â Given this projected burden of disease, efforts in understanding and developing new treatments for PDA are paramount. In ...
Myelodysplastic syndromes (MDS) are a group of clonal myeloid neoplasms characterised by blood cytopaenia, cellular dysplasia and predisposition to the development of acute myeloid leukaemia (AML).1,2 MDS are common in older individuals, with an incidence that varies from 2–12/100,000 inhabitants/year ...
Peritoneal carcinomatosis, defined as tumor dissemination in the peritoneal cavity, is a common manifestation of gastrointestinal malignancies. However, isolated peritoneal metastases (IPM) are relatively rare, though appendiceal tumors and peritoneal mesothelioma have a propensity to involve only the peritoneum. Cytoreductive ...
Despite substantial advances in cancer diagnosis and treatment, the long-term survival rate for many cancer patients remains dismal.1 More than 90% of cancer-related mortality is ascribed to disease resurgence months or years after adjuvant therapy, either in the form of local ...
As is the case with most solid tumors, gastrointestinal (GI) tumors are treated in a variety of modalities, which are used singularly or in combination, including surgery, targeted therapies, radiation, and chemotherapy. Survival rates by stage in colon and rectal ...
Neuroendocrine neoplasms (NENs) are a group of rare and heterogeneous malignancies that arise from neuroendocrine cells in most organs of the body. The presence, rather than absence of symptoms due to neuropeptides or hormones hypersecretion, distinguishes NENs in functioning and ...
Neuroendocrine tumours (NETs) is a collective term for a diverse range of neoplasms that arise from cells that originate in the endocrine and nervous systems and share common morphological and immunohistochemical features, including the presence of secretory granules. These tumours ...
Malignant tumours are relatively uncommon in children, especially considering the incidence of cancer in adults. The difficulty of performing meaningful studies due to the limited numbers of patients treated at each paediatric oncology centre has encouraged oncologists to embark on ...
Neuroendocrine tumours (NETs) are rare neoplasms that arise from neuroendocrine cells which are present throughout the body. NETs may be classified as functioning or non-functioning and are further differentiated based on the site of primary origin, histologic grade (low, intermediate ...
Despite many years of continuous effort, pancreatic carcinoma remains a highly lethal disease and a challenge to the medical community. Most patients will be diagnosed in an advanced stage of the disease and will be candidates for oncological palliative therapy ...
The primary myelodysplastic syndromes (MDS) are one of five major categories of myeloid neoplasms.1 Their actual incidence is unknown, but it has been suggested that it may be higher than estimated.2 Ageing is an important risk factor for the development ...
In the recent revised classification of neuroendocrine tumors,6 the size of 2cm seems to be a crucial value over which carcinoid tumors start to exhibit malignant behavior. In other words, if resection is accomplished in time, no local recurrence might ...
The process of cellular differentiation, proliferation, and apoptosis is a tightly regulated one with multiple interactions within the cell and the surrounding extracellular matrix. A simplistic schema of intracellular signaling is shown in Figure 1. Disruption of one or more components ...
Increased expression of intracellular annexin I is seen in bronchial epithelial cells grown in the presence of dexamethasone,9 and secreted annexin I appears to be proteolytically degraded by the human neutrophil elastase to an inactive form.10,11 Annexin I is a ...
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