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19 Results Found for “plasma exchange”
The first primary microangiopathic haemolytic anaemia was identified as thrombotic thrombocytopenic purpura (TTP) by Dr Moschowitz in 1924. At that time, the classic pentad of clinical features, still used today, included fever, erythrocyte fragmentation, thrombocytopenia, kidney injury and neurologic injury.1 It ...
Rat sarcoma virus (RAS) proteins are a family of prototypical oncogenes frequently mutated in human cancers. Mutations in the RAS gene account for 19% of all pathogenic alterations and are the subject of extensive research in molecular and clinical oncology.1 The ...
Welcome to the winter edition of European Oncology and Haematology. At the end of another year in which the field of oncology has reported new standards of care and improved outcomes in numerous types of cancer, we feature a range ...
Therapeutic plasma exchange (TPE) is an extracorporeal technique that involves separating a large volume of a patient’s plasma from the cellular components of the blood and replacing it with appropriate fluids.1 In patients with conditions that are induced and/...
The development of precision medicine relies on the identification of biomarkers for monitoring and detecting disease. Current studies of biomarker identification have focused on serum and plasma, but in doing so, they have missed a rich source of biomarkers: platelets.1 ...
The term paraneoplastic syndrome (PNS) was first described in the 1940s as the phenomenon that certain cancers manifest as symptoms not directly related to the tumor itself.1 Since then, there have been a multitude of reports on PNS, which is ...
Advances have been made in the use of genetically enhanced T cell therapy, in particular, chimeric antigen receptor (CAR) T cells. Such CAR T cells have been shown to be efficacious in erradicating a number of haematologic malignancies.1–3 CARs are ...
H-Ras, K-Ras, and N-Ras are the main members of Ras superfamily, which bind small molecules GTP and GDP interchangeably and can hydrolyze GTP to GDP. The Ras superfamily consists of more than 150 proteins and these can be classified under at ...
Classification The two basic forms of thrombotic microangiopathies, excluding disseminated intravascular coagulation (DIC), include thrombotic thrombocytopenic purpura (TTP), and hemolytic uremic syndrome (HUS). Early historic reports noted the presence of hemolytic anemia and thrombocytopenia in both disorders and suggested differentiation ...
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) belonging to the insulin receptor superfamily. The ALK gene is located on the short arm of chromosome 2 and was first identified as an oncogene activated by chromosomal translocation t(2;5)(p23;...
‘Haemovigilance’ is defined by the International Haemovigilance Network (IHN) as ‘a set of surveillance procedures covering the whole transfusion chain, from the collection of blood and its components to the follow-up of recipients, intended to collect and assess information on ...
Thrombotic thrombocytopenic purpura (TTP) is an acute prothrombotic disorder resulting from a deficiency of the von Willebrand factor cleavage protease ADAMTS13.1 The enzyme ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats) cleaves the peptide bond between Tyr-842 and Met-843 ...
Haemophilia B is an X-linked recessive coagulation disorder with an estimated incidence of 1 in 60,000 people.1,2 It is characterised by repeated bleeding, particularly into the joints and muscles, which can initiate a cascade of events leading to destruction of the synovium ...
Myeloproliferative disorders (MPDs) are haematopoietic stem cell malignancies characterised by overproduction of one or more mature myeloid lineage. The term ‘myeloproliferative syndrome’ was first introduced in 1951 by Dameshek,1 who defined chronic myeloid leukaemia (CML), polycythaemia vera (PV), essential thrombo-cythaemia (ET) ...
What should physicians and researchers expect from a professional membership? At the very least, we hope for a venue for peer interaction, opportunities for career development, and a way to maintain quality standards and currency within our chosen fields. Several ...
Immune-mediated haematological disorders are a heterogeneous group of disorders characterised by immune-mediated destruction of blood cells, leading to anaemia, neutropenia or thrombocytopenia or to a combination of two or all of them. Immune-mediated anaemia can be caused directly by destruction ...
Thrombotic thrombocytopenic pupura (TTP) is a life-threatening disease characterised by microangiopathic haemolytic anaemia, consumptive thrombocytopenia and various organ dysfunctions, such as neurological symptoms, renal damage and fever.1 In order to ensure best treatment responses, early diagnosis and appropriate intervention are ...
Lung cancer is the main cause of cancer deaths for both men and women in the US and worldwide. In the US, there were approximately 232,270 new cases diagnosed and 166,280 deaths due to this disease by the end of 2008.1 Non-small-cell cancer (...
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