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35 Results Found for “platelet aggregation”
The first primary microangiopathic haemolytic anaemia was identified as thrombotic thrombocytopenic purpura (TTP) by Dr Moschowitz in 1924. At that time, the classic pentad of clinical features, still used today, included fever, erythrocyte fragmentation, thrombocytopenia, kidney injury and neurologic injury.1 It ...
Acute myeloid leukaemia (AML) is a heterogeneous haematological malignancy characterized by the presence of ≥20% blasts in bone marrow or peripheral blood or the presence of defined genetic abnormalities.1 In 2020, there were an estimated 21,450 new patients with AML and 11,180 AML-related deaths ...
Haematopoietic stem cell transplantation (HSCT) has become the standard of care for many haematological malignancies, selected solid tumours and some non-malignant disorders.1 However, it can be associated with serious complications, in particular, veno-occlusive disease (VOD). Approximately 14 % of HSCT patients develop ...
Classification The two basic forms of thrombotic microangiopathies, excluding disseminated intravascular coagulation (DIC), include thrombotic thrombocytopenic purpura (TTP), and hemolytic uremic syndrome (HUS). Early historic reports noted the presence of hemolytic anemia and thrombocytopenia in both disorders and suggested differentiation ...
Thrombotic thrombocytopenic purpura (TTP) is an acute prothrombotic disorder resulting from a deficiency of the von Willebrand factor cleavage protease ADAMTS13.1 The enzyme ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats) cleaves the peptide bond between Tyr-842 and Met-843 ...
Phenotypic diversity within the β-thalassaemia syndromes has traditionally received considerable interest, with several molecular and environmental modifiers of disease severity so far described.1 Patients with transfusion-dependent β-thalassaemia major (TM) suffer the most severe form and show the highest mortality rates.1 ...
Phenotypic diversity within the β-thalassemia syndromes has traditionally received considerable interest, with several molecular and environmental modifiers of disease severity so far described.1 Patients with transfusion-dependent β-thalassemia major (TM) suffer the most severe form and show the highest mortality rates.1 ...
Introduction to Decision Analysis Some statisticians might question whether Hamlet could have been saved by clinical decision analysis. In his famous soliloquy, Hamlet pondered: “To be or not to be—that is the question.” With some refinement, this existential questioning ...
Human cytomegalovirus (CMV) is a common human pathogen that infects the majority of the world’s population. CMV is a large species-specific virus that co-evolved with its host for many thousands of years. Since CMV adapted to persist in immunocompetent ...
When a blood vessel is injured, platelets adhere to the exposed subendothelium (platelet adhesion). The platelets are activated (platelet activation) and secrete their granule contents (platelet secretion). The granule contents include platelet agonists (adenosine diphosphate [ADP] and serotonin) that, by ...
Inherited bleeding disorders are rare in the general population. Nevertheless, the most common bleeding disorders, haemophilia and von Willebrand disease (VWD), occur in one in 5,000 males and 1% of the general population.1 Since fibrin formation or platelet aggregation in these patients ...
Venomous snakebites are still a public health problem in tropical countries. Even in metropolitan areas, such as Bangkok, green pit viper (Cryptelytrops albolabris and C. macrops) bites are still prevalent. As we are invading their territory, they adapt to live ...
The transfusion of allogeneic blood products is a complex medical therapy relying on materials that are often available only in short supply and carry a number of substantial risks for the recipient. Perhaps the most feared complication of transfusion is ...
The transfusion of allogeneic blood products is a complex medical therapy relying on materials that are often available only in short supply and carry a number of substantial risks for the recipient. Perhaps the most feared complication of transfusion is ...
In the case of an isolated chronic thrombocytopenia in an adult, the diagnostic procedure is well established. First, several causes must be ruled out. These include: • false thrombocytopenia diagnosis caused by platelet aggregation and clumping in the presence of ethylenediaminetetraacetic ...
Inherited Platelet Disorders Inherited Platelet Disorders Inherited platelet disorders constitute a group of rare diseases giving rise to bleeding syndromes of varying severity. The defects concern the number or the function of platelets or, in some cases, both.1–3 Platelets are ...
von Willebrand disease (VWD) is a bleeding disorder caused by quantitative or qualitative defects of von Willebrand factor (VWF). VWF is a high-molecular-weight (HMW) glycoprotein that plays an essential part in the early phases of haemostasis by promoting platelet adhesion ...
von Willebrand disease (VWD) is the most common inherited bleeding disorder and is characterised by low levels of and/or abnormal function in the plasma protein von Willebrand factor (VWF). Typically, laboratory investigation entails initial plasma testing of factor VIII ...
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