Brian Van Tine

Brian Van Tine is Assistant Professor of Medicine in the Department of Medicine at Washington University in St. Louis, Missouri, USA. He is the Sarcoma Program Director at the Alvin J. Siteman Cancer Center. He received his Bsc from the Departments of Chemistry and Biochemistry at the University of Arizona in 1995. He completed his MD and PhD at the University of Alabama at Birmingham in 2005. He then came to Washington University in St. Louis/Barnes – Jewish Hospital, where he completed an Internal Medicine Residency and Medical Oncology Fellowship. He is the sarcoma medical oncologist for the mid-west region surrounding St. Louis, focusing his efforts on translating basic science observations to clinical trials. His laboratory is dedicated to understanding the metabolomics deficiencies found in sarcomas, as they can be therapeutically targeted. His laboratory has identified argininosuccinate synthetase 1 deficiencies in sarcomas that can be treated with pegylated-arginine demiminase. Among other research is the development of biomarker driven metabolic therapies for all sarcomas and identification of a metabolic deficiency in synovial sarcoma that can also be therapeutically exploited.