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PARP inhibitors as first-line maintenance therapy in ovarian cancer: How can data from ESGO 2022 guide clinical practice?

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Ovarian Cancer, Gynaecological Oncology Watch Time: 57 mins

touchCONGRESS PARP inhibitors as first-line maintenance therapy in ovarian cancer: How can data from ESGO 2022 guide clinical practice?

Watch this two-part activity exploring the latest data on the use of PARP inhibitors in first-line maintenance therapy in ovarian cancer. Filmed following the ESGO European Congress on Gynaecological Oncology 2022.

Part 1: Watch gynaecological cancer expert Prof. Jonathan Ledermann review key data from ESGO 2022 Watch Now

Part 2: Watch leading experts consider what these data may mean for global and regional practice Select An Interview

  • Part 1: Data Review
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Introduction
Clinical trial data for PARP inhibitors in the first-line maintenance setting
Real-world data for PARP inhibitors in the first-line maintenance setting
Patient-related considerations for PARP inhibitors in the first-line maintenance setting
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Overview

Watch Prof. Jonathan Ledermann summarize and share his interpretation of the latest data from ESGO 2022 on the use of PARP inhibitors in the first-line maintenance setting in advanced ovarian cancer. During the presentation, he considers:

  • The latest clinical trial data relating to PARP inhibitors as a first-line maintenance treatment
  • Real-world data on the use of PARP inhibitors as a maintenance treatment
  • How the data presented at the congress may impact clinical practice

Prof. Jonathan Ledermann is a professor of medical oncology and clinical director at UCL Cancer Institute, University College London, and a consultant medical oncologist at UCL Hospitals, London, UK. read more

Prof. Ledermann specializes in the treatment of gynaecological cancers and has led several national and international trials in ovarian cancer during 22 years as director of the Cancer Research UK & UCL Cancer Trials Centre. He is a senior investigator for the NIHR (National Institute for Health and Care Research) and a fellow of the Academy of Medical Sciences and editor for the ESMO (European Society for Medical Oncology) clinical practice guidelines on gynaecological cancers.

Prof. Ledermann is the past vice president of ESGO (European Society of Gynaecological Oncology) and has previously been chair of the NCRI (National Cancer Research Institute) UK Gynaecological Cancer Trials Group, chair of the Rare Tumour Group of the CICG (Gynecological Cancer InterGroup) and council member of BGCS (British Gynaecological Cancer Society) and IGCS (International Gynaecological Cancer Society).

Prof. Ledermann serves on editorial boards of several scientific journals and has published widely in the areas of clinical trials in gynaecological cancers, experimental therapeutics, guidelines, and education in gynaecological malignancies.

Prof. Jonathan Ledermann discloses: Advisory board and speaker fees from Artios Pharma, AstraZeneca, Bristol Myers Squibb, Clovis Oncology, Eisai, Ellipses, GlaxoSmithKline, Merck/Merck Sharp & Dohme, Nuvation, Pfizer and VBL Therapeutics. Independent data monitoring committee roles for Mersana and Regeneron. Research grant (to university) from AstraZeneca and Merck/Merck Sharp & Dohme. Clinical trials (to hospital) for AstraZeneca, Clovis Oncology, Eisai, GlaxoSmithKline, Merck/Merck Sharp & Dohme and Pfizer. Non-financial interests with European Society of Gynaecological Oncology (leadership role 2019–2021); Other interests with SAGE Publishing (associate editor: Therapeutic Advances in Medical Oncology).

  • Part 2: Expert interviews
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Dr David Tan
Watch Time: 09:24
National University Cancer Institute, Singapore
 
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In this interview, Dr David Tan answers the following questions:

  • To what extent do PARP inhibitors improve patient outcomes as a first-line maintenance therapy in patients with advanced ovarian cancer?
  • Should all patients with advanced ovarian cancer be tested for HRD, and how useful is HRD-status as a guide for the use of PARP inhibitors?
  • What insights do real-world data presented at ESGO 2022 add to the first-line maintenance landscape for advanced ovarian cancer?
  • Based on data presented at ESGO 2022, how are PARP inhibitors most likely to impact future clinical practice for patients with advanced ovarian cancer?
  • What factors are used to decide which patients with advanced ovarian cancer receive maintenance therapy with PARP inhibitors (and which PARP inhibitor) after first-line chemotherapy?

Dr David Tan is a consultant medical oncologist at the National University Cancer Institute, Singapore and an associate professor in the Department of Medicine at the Yong Loo Lin School of Medicine, National University of Singapore, where he is also principal investigator at the Cancer Science Institute. read more

Dr Tan’s primary clinical and research interests are in gynaecological cancers, precision oncology and early phase trials. He has authored over 100 peer-reviewed scientific papers and received several awards for his research.

Dr Tan is currently the head of the Innovation Transfer Office at National University Health System (NUHS). He was the founding President of the GyneCologic Cancer Group Singapore (GCGS), and past-chairman of the Asia-Pacific Gynecologic Oncology Trials (APGOT) Group. He currently also chairs the Cervical Cancer Research Network (CCRN) and is a member of the executive board of directors of the Gynecological Cancer InterGroup (GCIG).

Dr David Tan discloses: Consultancy fees from AstraZeneca, Boeringer Ingelheim, Eisai, Genmab, GlaxoSmithKline, Merck Serono, Merck Sharp & Dohme and Roche. Research funding and support from AstraZeneca, Bayer, Bristol Myers Squibb, Eisai, Karyopharm, Merck Sharp & Dohme, and The National Medical Research Council Singapore and the Pangestu Family Foundation Gynaecological Cancer Research Fund. Stock ownership in Asian Microbiome Library (AMiLi).

Dr Anna Tinker
Watch Time: 09:31
BC Cancer, Vancouver, Canada
 
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In this interview, Dr Anna Tinker answers the following questions:

  • To what extent do PARP inhibitors improve patient outcomes as a first-line maintenance therapy in patients with advanced ovarian cancer?
  • Should all patients with advanced ovarian cancer be tested for HRD, and how useful is HRD-status as a guide for the use of PARP inhibitors?
  • What insights do real-world data presented at ESGO 2022 add to the first-line maintenance landscape for advanced ovarian cancer?
  • Based on data presented at ESGO 2022, how are PARP inhibitors most likely to impact future clinical practice for patients with advanced ovarian cancer?
  • What factors are used to decide which patients with advanced ovarian cancer receive maintenance therapy with PARP inhibitors (and which PARP inhibitor) after first-line chemotherapy?

Dr Anna Tinker is a medical oncologist at British Columbia Cancer, Vancouver Centre and a clinical associate professor in the Department of Medicine at the University of British Columbia, Canada. read more

Dr Tinker’s clinical expertise is in the treatment of women with gynaecological cancers. Her research interests are in the area of clinical trial development, immunotherapy and translational research.

Dr Tinker is presently chair of the Provincial Gyne Oncology Tumour Group and is also director of OvCaRe’s Ovarian Cancer Outcomes Unit. She is an active member of the Canadian Cancer Trials Group, participating as study chair, a member of the Ovarian Cancer Working Group Committee and on the Investigational New Drug Committee, and she serves on the Gynecologic Cancers Steering Committee – Ovarian Task Force for the National Cancer Institute (US).

Dr Anna Tinker discloses: Honoraria or advisory board fees from AstraZeneca, Eisai, GlaxoSmithKline and Merck. Research funding from AstraZeneca. Travel funding from GlaxoSmithKline.

Prof. Jonathan Ledermann
Watch Time: 11:26
UCL Cancer Institute, London, UK
 
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In this interview, Prof. Jonathan Ledermann answers the following questions:

  • To what extent do PARP inhibitors improve patient outcomes as a first-line maintenance therapy in patients with advanced ovarian cancer?
  • Should all patients with advanced ovarian cancer be tested for HRD, and how useful is HRD-status as a guide for the use of PARP inhibitors?
  • What insights do real-world data presented at ESGO 2022 add to the first-line maintenance landscape for advanced ovarian cancer?
  • Based on data presented at ESGO 2022, how are PARP inhibitors most likely to impact future clinical practice for patients with advanced ovarian cancer?
  • What factors are used to decide which patients with advanced ovarian cancer receive maintenance therapy with PARP inhibitors (and which PARP inhibitor) after first-line chemotherapy?

Prof. Jonathan Ledermann is a professor of medical oncology and clinical director at UCL Cancer Institute, University College London, and a consultant medical oncologist at UCL Hospitals, London, UK. read more

Prof. Ledermann specializes in the treatment of gynaecological cancers and has led several national and international trials in ovarian cancer during 22 years as director of the Cancer Research UK & UCL Cancer Trials Centre. He is a senior investigator for the NIHR (National Institute for Health and Care Research) and a fellow of the Academy of Medical Sciences and editor for the ESMO (European Society for Medical Oncology) clinical practice guidelines on gynaecological cancers.

Prof. Ledermann is the past vice president of ESGO (European Society of Gynaecological Oncology) and has previously been chair of the NCRI (National Cancer Research Institute) UK Gynaecological Cancer Trials Group, chair of the Rare Tumour Group of the CICG (Gynecological Cancer InterGroup) and council member of BGCS (British Gynaecological Cancer Society) and IGCS (International Gynaecological Cancer Society).

Prof. Ledermann serves on editorial boards of several scientific journals and has published widely in the areas of clinical trials in gynaecological cancers, experimental therapeutics, guidelines, and education in gynaecological malignancies.

Prof. Jonathan Ledermann discloses: Advisory board and speaker fees from Artios Pharma, AstraZeneca, Bristol Myers Squibb, Clovis Oncology, Eisai, Ellipses, GlaxoSmithKline, Merck/Merck Sharp & Dohme, Nuvation, Pfizer and VBL Therapeutics. Independent data monitoring committee roles for Mersana and Regeneron. Research grant (to university) from AstraZeneca and Merck/Merck Sharp & Dohme. Clinical trials (to hospital) for AstraZeneca, Clovis Oncology, Eisai, GlaxoSmithKline, Merck/Merck Sharp & Dohme and Pfizer. Non-financial interests with European Society of Gynaecological Oncology (leadership role 2019–2021); Other interests with SAGE Publishing (associate editor: Therapeutic Advances in Medical Oncology).

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Learning Objectives & Overview
Overview

Stay up to date with the latest data on the use of PARP inhibitors as first-line maintenance treatment for ovarian cancer in this two-part activity, filmed following the ESGO European Congress on Gynaecological Oncology 2022.

Learning Objectives

After watching this activity, participants should be better able to:

  • Outline the latest clinical trial data for PARP inhibitors in the first-line maintenance setting for advanced ovarian cancer
  • Describe real-world data on the use of PARP inhibitors in the first-line maintenance setting for advanced ovarian cancer
  • Discuss how the clinical trial and real-world data may impact the use of PARP inhibitors in clinical practice
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