Gastrointestinal Oncology
Watch Time: 7 mins

Myriam Chalabi, ESMO 2022: Neoadjuvant immune checkpoint inhibition in locally advanced MMR-deficient colon cancer: the NICHE-2 study

Published Online: September 11th 2022

Neoadjuvant immunotherapy has shown promising responses in several cancer types. In this touchONCOLOGY interview Dr Myriam Chalabi (Netherlands Cancer Institute, Amsterdam, Netherlands) discusses the NICHE-2 study results, investigating patients with non-metastatic deficient DNA mismatch repair (dMMR) colon cancer, treated with one dose of ipilimumab and two doses of nivolumab and underwent surgery ≤6 weeks of registration.

The abstract entitled ‘Neoadjuvant immune checkpoint inhibition in locally advanced MMR-deficient colon cancer: the NICHE-2 study‘ Abstract LBA7, was presented at European Society for Medical Oncology (ESMO) 2022.

Questions:

  1. What are the unmet needs in the treatment of locally advanced MMR deficient colon cancer? (0:21)
  2. What were the aims, design and eligibility criteria of the NICHE-2 study? (1:29)
  3. What were the efficacy and safety endpoints and how well were they achieved? (2:07)
  4. What is the potential role of neoadjuvant immunotherapy in this treatment setting? (3:09)
  5. What questions remain unanswered and what further research is needed? (5:35)

Disclosures: Myriam Chalabi receives grant/research support from Roche, BMS and MSD; and is on the advisory board for BMS, and Numab.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Katey Gabrysch.

Filmed in coverage of ESMO 2022

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