Welcome to the Fall edition of Oncology & Hematology Review (US). This edition, expertly introduced by Shaji Kumar, features a wide range of timely and concise review articles on some of the most important topics in the field including breast cancer, cervical cancer, gastrointestinal cancer, genitourinary cancer, and hematologic malignancies. In the lung cancer section Dr Fenton explores current and future therapeutics for patients with non-small cell lung cancer and known activating mutations in EGFR, and Scagliotti and Novello focus on the investigational new agent rociletinib in the same patient set. Dr Warner discusses the important topic of knowledge management for oncologists and Friedman and Postow discuss the latest developments in managing immunotherapy-related side effects.
We hope this collection of topical articles provide useful information relevant to your practice and interests.
Foreword – Oncology & Hematology Review (US), 2015;11(2):
Welcome to the latest edition of Oncology & Hematology Review, which features a wide variety of articles covering topics of interest to oncologist and hematologists, as well as the wider medical community. This issue begins with a timely article by Warner about knowledge management for oncologists. In the current era of exciting advances in oncology, […]
Grappling with the Data Explosion in Oncology
Oncologists are facing challenging times. Cancer is forecast to become the leading cause of death in the US fairly soon, and is already the leading cause of disability-adjusted life years lost.1 As the workload of the practicing oncologist inevitably increases, the challenge is only compounded by the explosion of knowledge in the cancer space. As […]
Trends in the Cost-effectiveness of Chemoprevention for Breast Cancer—2001 to 2015
Breast cancer is the most commonly diagnosed cancer and is the second most common cause of cancer-related death among women in the US, leading to over 40,000 deaths annually.1,2 The cost of diagnosing, treating, and providing long-term follow-up care for these patients has a major impact on health systems. Estimates of the average annual costs […]
Why We Need to Continue to Research Ways to Improve the Treatment of Locally Advanced Cervical Cancer
Cervical cancer remains one of the leading causes of cancer-related morbidity and mortality worldwide, and is the fourth leading cause of cancer death in women.1 Human papilloma virus (HPV), particularly types 16 and 18, is significantly associated with subsequent development of cervical cancer, with an increased risk also seen among smokers.2 Cervical cancer incidence has […]
Individualized Treatment of Diffuse Large B-cell Lymphoma— The Evolving Role of Molecular-subtype-specific Therapy
Individualized treatment of patients with malignancy is feasible in modern oncology due to improved molecular techniques and the development of novel, targeted agents. Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL). Standard frontline therapy consists of combined immunochemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Although outcomes for patients with […]
Monoclonal Antibodies for the Treatment of Multiple Myeloma— A New Paradigm
Multiple myeloma (MM) is the second most common hematologic malignancy representing 1.6 % of all new cancer cases in the US. The rates for new MM cases have been rising on an average of 0.8 % each year over the last 10 years. While the survival of patients with MM has steadily improved over the […]
Rociletinib—An Investigational Therapy in Patients with Previously Treated EGFR Mutant-positive Non-small Cell Lung Cancer
In 2015, the prevalence of patients living with lung cancer in the US is more than 430,000 and the incidence of new cases of lung cancer is around 221,200.1 Deaths from lung cancer are estimated to be 158,040.1 In Europe, in 2012, 410,000 patients were diagnosed with lung cancer and 354,000 died from the disease.2,3 […]
Current and Future Therapeutics for Patients with Non-small Cell Lung Cancer and Known Activating Mutations in Epidermal Growth Factor Receptor
Lung cancer is the most common cancer in the US with an estimated 221,200 new cases in 2015. An estimated 158,040 patients will die of the disease this year.1 The overall 5-year survival rate for all stages of lung cancer is 17 %, and for advanced disease, 4 %.1 Lung cancer will account for approximately […]
Radium223—Where Does It Fit in the Metastatic Castration-resistant Prostate Cancer Treatment Landscape?
After the Food and Drug Administration (FDA) approved docetaxel for metastatic castration-resistant prostate cancer (mCRPC) in 2004, there were limited advances until 2010, when sipuleucel-T marked the first in a series of FDA approvals. Following the addition of immunotherapy (sipuleucel-T), advanced androgen receptor-targeted agents (abiraterone acetate [AA] plus prednisone in 2011 and enzalutamide in 2012), […]
American Society of Clinical Oncology 2015— Highlights of Non-colorectal Gastrointestinal Cancers
The 2015 annual American Society of Clinical Oncology meeting brought refinements rather than major practice changes to the field of noncolorectal gastrointestinal (GI) cancers, with one notable exception and that is for the emerging endorsement of the role of immune therapies in these diseases. Arguably the most important observation from the meeting overall was the […]
“New” Drugs in Localized Rectal Cancer
Colorectal cancer will be diagnosed in 132,700 individuals in the US this year alone with rectal cancer being that of 39,610 patients.1 In contrast to the treatment developments in metastatic colorectal cancer, the treatment of locally advanced rectal cancer has remained at a standstill for the past decade with little development of novel therapies. 5-Fluorouracil […]
Making Sense of the Advances in the Treatment of Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death, with a rising global incidence.1 The majority of HCC occurs in the setting of liver cirrhosis, mainly due to hepatitis C virus (HCV) infection, hepatitis B viral infection, alcohol consumption, or nonalcoholic fatty liver disease. The most important development in HCC is the advent of […]
Managing Immunotherapy-related Side Effects
The field of oncology immunotherapeutics has exploded recently with the development of immune-checkpoint inhibitors. These drugs enhance antitumor immunity by blocking negative regulators of T-cell function that exist both on immune cells and on tumor cells. There are two classes of immune-checkpoint inhibitors: currently the Food and Drug Administration (FDA) has approved cytotoxic T-lymphocyte antigen […]
Genomics and Precision Cancer Medicine
Advancing technology has led to the successful utilization of nextgeneration sequencing (NGS) for assessing cancer susceptibility, diagnosis, prognosis, and treatment.1,2 Currently, matching therapies that target single-nucleotide variations, gene fusions, or copy number variations are approved for clinical use across various tumors. However, clinical application of genomic testing presents some potential challenges, including consent, tissue acquisition, […]
Significance of Ras Signaling in Cancer and Strategies for its Control
H-Ras, K-Ras, and N-Ras are the main members of Ras superfamily, which bind small molecules GTP and GDP interchangeably and can hydrolyze GTP to GDP. The Ras superfamily consists of more than 150 proteins and these can be classified under at least five sub-families viz: the Ras, Rab, Rho, Ran, and Arf families.1 Ras oncoproteins […]
European Oncology & Haematology Highlights
Chronic Myeloid Leukaemia – The Choice of Therapy and Future Perspectives
The overwhelming majority of patients diagnosed with chronic phase chronic myeloid leukaemia (CP-CML) can achieve long-term survival with a good quality of life. In a recent review, it has been suggested that CML patients responsive to tyrosine kinase inhibitors (TKIs) might become a chronic disease, such as diabetes or hypertension, requiring maintenance treatment.1 If we […]
The Treatment of Chronic Myeloid Leukaemia (CML) in the Era of Tyrosine Kinase Inhibitors – What is New in the Battle of CML?
As the development of BCR-ABL1 targeting treatments has continued, patients with chronic phase chronic myeloid leukaemia (CML‑CP) were shown to have similar survival rates in all age groups to that of general population in the era of tyrosine kinase inhibitors (TKIs).1 First, imatinib and subsequently the second-generation TKIs (2GTKIs) (nilotinib and dasatinib) revolutionised the treatment […]
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