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Rat sarcoma virus (RAS) proteins are a family of prototypical oncogenes frequently mutated in human cancers. Mutations in the RAS gene account for 19% of all pathogenic alterations and are the subject of extensive research in molecular and clinical oncology.1 The RAS family consists of three major isoforms, namely the Harvey rat sarcoma virus (HRAS), the neuroblastoma RAS […]

Alessandra Tedeschi, EHA 2019 – Ibrutinib for First-line Treatment of CLL

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Published Online: Jun 28th 2019

We are joined by Alessandra Tedeschi at EHA 2019 to discuss her presentation on the five-year follow-up of patients receiving ibrutinib for first-line treatment of chronic lymphocytic leukemia (CLL).

Questions

1. How does ibrutinib fit into the treatment paradigm for chronic lymphocytic leukemia? (0:05)
2. What were the major findings of the long-term follow-up of the RESONATE-2 study? (0:27)
3. Which patient subgroups were most likely to experience durable responses? (1:09)
4. What is the long-term safety profile of ibrutinib? (1:38)
5. What are the treatment options for patients who discontinue ibrutinib therapy? (2:13)

Alessandra Tedeschi has no conflicts of interest to declare in relation to this video.

Filmed at the European Hematology Association (EHA) 24th congress 2019, Amsterdam, Netherlands.

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