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Courtney DiNardo, EHA 2020: Venetoclax plus Azacitadine in AML and the VIALE-A Study

Published Online: June 26th 2020

Dr Courtney DiNardo (The University of Texas MD Anderson Cancer Center, Houston, United States) joins touchONCOLOGY to discuss the key findings from the VIALE-A study and the safety and efficacy of venetoclax plus azacitadine in patients with acute myeloid leukaemia and (NCT02203773 and NCT02287233.)

Questions

1. What are the limitations of current therapeutic options for patients with acute myeloid leukaemia who cannot receive or tolerate intensive chemotherapy or a bone marrow transplant? (0:04)
2. Could you tell us about the VIALE-A study and its major findings? (1:02)
3. What were the safety findings of this study, and what, if any, was the incidence of tumour lysis syndrome? (4:20)
4. Which patients are most likely to benefit from this treatment regimen and in which patients is it contraindicated? (6:28)

Abstract LB2601, A Randomized, Double-Blind, Placebo-Controlled Study Of Venetoclax With Azacitidine vs Azacitidine In Treatment-Naïve Patients With Acute Myeloid Leukemia Ineligible for Intensive Therapy-VIALE-A, was presented as a late-breaking abstract at EHA25 Virtual and is available here.

Timing of response to venetoclax combination treatment in older patients with acute myeloid leukemia, was presented at ASCO20 Virtual as Abstract 7531, and at EHA25 Virtual as Abstract EP535.

Speaker disclosure: The VIALE-A study was supported by Abbvie.

Support: Interview and filming supported by Touch Medical Media in collaboration with Earned Media.

Filmed at the Virtual Edition of the 25th European Hematology Association Annual Congress (EHA25 Virtual), June 2020.

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