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María-Victoria Mateos, EHA 2020: TOURMALINE-MM4 study

Published Online: July 6th 2020

Dr María-Victoria Mateos, (Associate Professor of Medicine, Director of Myeloma Unit, University Hospital of Salamanca, Salamanca, Spain) explores unmet needs in the treatment of patients with newly-diagnosed multiple myeloma, and discusses the major findings of the TOURMALINE-MM4 study and the potential of ixazomib in patients no undergoing autologous stem cell transplant.


  1. What are the limitations of current options for maintenance therapy in patients with newly-diagnosed multiple myeloma not undergoing autologous stem cell transplant (ASCT)? (0:04)
  2. What is the mechanism of action of ixazomib, and what precautions are associated with its use? (1:05)
  3. Could you give us an overview of the concept of switch maintenance, and the design of the TOURMALINE-MM4 study? (2:03)
  4. What were the major efficacy and safety findings of this study? (5:06)
  5. What have the other TOURMALINE studies taught us about the use of ixazomib in the treatment of multiple myeloma? (8:39)

Abstract S200, Ixazomib vs Placebo as Post-Induction Maintenance Therapy in Newly Diagnosed Multiple Myeloma (NDMM) Patients (pts) Not Undergoing Autologous Stem C Transplant (ASCT): Phase 3 TOURMALINE-MM4 Trial, was presented at EHA25 Virtual, June 2020.

Speaker disclosure: The TOURMALINE-MM4 study was supported by Takeda.

Support: Interview and filming supported by Touch Medical Media in collaboration with W20 Group.

Filmed at the Virtual Edition of the 25th European Hematology Association Annual Congress (EHA25 Virtual), June 2020.

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