An Introduction to Myelodysplastic Syndromes
Myelodysplastic syndromes include a range of bone marrow malignancies characterised by cytopenia and ineffective haematopoiesis, resulting in chronic anaemia and the risk of progression to acute myeloid leukaemia. The current standard of care ranges from supportive care to allogeneic stem cell transplant until recently, progress had lagged behind other blood cancers, with no new approved therapies in over a decade. However, in July 2020 the FDA approved the first oral treatment, a fixed-dose combination of the hypomethylating agent decitabine and the cytidine deaminase inhibitor cedazuridine. Luspatercept-aamt has also recently been approved for treatments in patients with anaemia who require red blood cell transfusions and have not achieved success with an erythropoiesis-stimulating agent.
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Myelodysplastic Syndromes Content
Nicolaus Kröger, ASH 2018 – Treatment of Myelodysplastic Syndrome in Elderly Patients
Professor Nicolaus Kröger spoke to us at ASH 2018 about the major unmet needs in the treatment of myelodysplastic syndrome in elderly patients, and his phase III study comparing 5-azacytidine induction followed by allogeneic stem cell transplantation versus continuous 5-azacytidine according to donor availability in elderly patients with myelodysplastic syndrome. Questions: 1. What are the […]
Transient Elastography for the Detection of Hepatic Iron Overload in Patients with Myelodysplastic Syndrome
European Oncology & Haematology, 2016;12(2):103–6 DOI: https://doi.org/10.17925/EOH.2016.12.02.103
In myelodysplastic syndrome (MDS), iron overload (IOL) is the result of multiple red blood cell (RBC) transfusions and increased iron absorption. The cause for the latter is low hepcidin levels due to an ineffective erythropoiesis.1 Increased iron absorption contributes to IOL, but chronic RBC transfusions are considered the main cause of IOL.2 IOL can lead […]
Myelodysplastic Syndromes – The Epigenetic Model for Drug Development?
European Oncology & Haematology, 2016;12(1):13–4 DOI: https://doi.org/10.17925/EOH.2016.12.01.13
Epigenetic dysregulation in myelodysplastic syndromes – how important is it? Our understanding of the biology and pathogenesis of myelodysplastic syndromes (MDS) has evolved dramatically in the last two decades. Evidence of an epigenetic background of the disease identified by a hypermethylation of specific genes and promoter-associated CpG islands was reported in the late 1990s1and first […]
Myelodysplastic Syndromes – Just a Matter of Age?
Oncology & Hematology Review, 2016;12(1):20–1 DOI: https://doi.org/10.17925/OHR.2016.12.01.20
The myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal hematologic disorders, characterized by inefficient hematopoiesis, myeloid dysplasia, and an increased risk for developing acute myeloid leukemia (AML).1,2 In the majority of patients, morbidity and mortality are the result of progressive cytopenias, but transformation to AML is observed in approximately one-third of patients. MDS is […]
Lenalidomide – A Brief Review of its Use in Myelodysplastic Syndromes
European Oncology & Haematology, 2015;11(2):141–6 DOI: https://doi.org/10.17925/EOH.2015.11.02.141
Myelodysplastic Syndromes and 5q Deletion Myelodysplastic syndromes (MDS) are a group of rare blood disorders that occur as a result of abnormal development of blood cells within the bone marrow. MDS may progress to life-threatening failure of the bone marrow or develop into an acute leukaemia. It affects, most commonly, the elderly population, with median […]
A Comprehensive Overview of the Role of Azacitidine in the Management of Myelodysplastic Syndromes and Acute Myeloid Leukaemia
European Oncology & Haematology, 2014;10(2):89–95 DOI: https://doi.org/10.17925/EOH.2014.10.2.89
The myelodysplastic syndromes (MDS) are a heterogeneous group of haematological disorders characterised by ineffective haematopoiesis with associated cytopenias and a hypercellular bone marrow (BM) with dysplastic changes.1 Patients with MDS have a variable reduction in the production of normal red blood cells (RBCs), platelets, and mature granulocytes. This often results in a variety of systemic […]
Prognostic Implications of Cytogenetic Features in Myelodysplastic Syndromes
Oncology & Hematology Review (US), 2013;9(1):60-7 DOI: https://doi.org/10.17925/OHR.2013.09.1.60
Myelodysplastic Syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell diseases characterized by morphologic changes in the bone marrow, peripheral cytopenia(s), and susceptibility to bone marrow failure with or without progression to Acute Myeloid Leukemia (AML). Although there is an inherited predisposition to develop MDS/ AML in patients with congenital bone marrow failure […]
Treatment Options for Myelodysplastic Syndromes
European Oncology & Haematology, 2011;7(3):200-2 DOI: https://doi.org/10.17925/EOH.2011.07.03.200
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal haematopoietic stem cell disorders that impair normal haematopoiesis, resulting in a variable number of cytopenias and a potential to evolve into acute myeloid leukaemia (AML).1 With a median age at diagnosis around 70 years, MDS typically affects the elderly.1,2 Hence, there is much morbidity and mortality […]
Treatment Options for Myelodysplastic Syndromes
US Oncology & Hematology, 2011;7(2):143-5 DOI: https://doi.org/10.17925/OHR.2011.07.2.143
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell disorders that impair normal hematopoiesis, resulting in a variable number of cytopenias and a potential to evolve into acute myeloid leukaemia (AML).1 With a median age at diagnosis around 70 years, MDS typically affects the elderly.1,2 Hence, there is much morbidity and mortality […]
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