Questions<\/strong>
\n1. What is favezelimab (MK4280) and its mechanism of action? (00:14-00:39)<\/p>\n2. What was the rationale for using favezelimab in combination with pembrolizumab in patients with microsatellite stable metastatic colorectal cancer that had progressed on two or more prior therapies? (00:39-01:33)<\/p>\n
3. Could you give us an overview of the phase I study and its findings? (01:33-03:08)<\/p>\n
4. Which patients had the best response to this combination? (03:08-03:30)<\/p>\n
5. What will be the next steps in the clinical development of favezelimab in this treatment setting? (03:30-04:08)<\/p>\n
6. What do you think is the most important aspect to consider with regards to immunotherapy in this patient subset? (04:08-04:42)<\/p>\n
Disclosures<\/strong>: Research: Novartis, Roche, Thermo Fisher, AstraZeneca, Taiho, BeiGene. Consultant\/Advisor: Roche\/Genentech, F.Hoffmann\/La Roche, Ellipses Pharma, Neomed Therapeutics1 Inc, Boehringer Ingelheim, Janssen Global Services, SeaGen, TFS, Alkermes, Thermo Fisher, Bristol-Mayers Squibb, MabDiscovery, Anaveon. Travel Grants: Bristol-Mayers Squibb, Merck Sharp & Dohme, Menarini, Glycotope. Speakers Bureau: Merck Sharp & Dohme, Roche, Thermo Fisher, Lilly. Clinical Trials PI or Co-PI (Institution): Affimed Gmbh, Amgen SA, Anaveon AG, AstraZeneca AB, Biontech Gmbh, Catalym Gmbh, Cytomx, F.Hoffmann, La Roche Ltd, F-Star Beta Limited, Genentech Inc, Genmab B.V., Hutchison Medipharma Limited, Icon, Imcheck Therapeutics, Immunocore Ltd, Janssen-Cilag SA, Medimmune Llc, Merck Kgga, Novartis Farmac\u00e9utica, S.A, Peptomyc, Ribon Therapeutics, Roche Farma SA, Seattle Genetics Inc, Symphogen A\/S, Taiho Pharma Usa Inc.<\/p>\nSupport<\/strong>: Interview and filming supported by Touch Medical Media. Interview conducted by Helen Fowler.<\/p>\nFilmed in coverage of the 2021 ASCO Annual Meeting.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"touchONCOLOGY joins Dr Elena Garralda (Vall d’Hebron Institute of Oncology, Barcelona, Spain) at ASCO 2021 to discuss favezelimab in metastatic colorectal cancer. The abstract \u2018A phase 1 first-in-human study of the anti-LAG-3 antibody MK4280 (favezelimab) plus pembrolizumab in previously treated, advanced microsatellite stable colorectal cancer (NCT02720068)\u2019 (abstract number 3584) was presented at the 2021 ASCO […]<\/p>\n","protected":false},"featured_media":40303,"template":"","class_list":["post-40302","media_gallery","type-media_gallery","status-publish","has-post-thumbnail","hentry","vocabulary_1-colorectal-cancer","video_categories-asco-highlights"],"acf":[],"_links":{"self":[{"href":"https:\/\/touchoncology.com\/wp-json\/wp\/v2\/media_gallery\/40302"}],"collection":[{"href":"https:\/\/touchoncology.com\/wp-json\/wp\/v2\/media_gallery"}],"about":[{"href":"https:\/\/touchoncology.com\/wp-json\/wp\/v2\/types\/media_gallery"}],"version-history":[{"count":1,"href":"https:\/\/touchoncology.com\/wp-json\/wp\/v2\/media_gallery\/40302\/revisions"}],"predecessor-version":[{"id":40304,"href":"https:\/\/touchoncology.com\/wp-json\/wp\/v2\/media_gallery\/40302\/revisions\/40304"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/touchoncology.com\/wp-json\/wp\/v2\/media\/40303"}],"wp:attachment":[{"href":"https:\/\/touchoncology.com\/wp-json\/wp\/v2\/media?parent=40302"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}