{"id":50588,"date":"2022-07-07T16:56:49","date_gmt":"2022-07-07T15:56:49","guid":{"rendered":"https:\/\/touchoncology.com\/?post_type=media_gallery&p=50588"},"modified":"2022-07-07T17:01:12","modified_gmt":"2022-07-07T16:01:12","slug":"axel-merseburger-asco-2022-highlights-in-prostate-cancer-clinical-trials-phase-3-trial-of-shr3680-enzamet-trial-magnitude-trial-propel-trial-phase-2-lutetium-177-trial-and-phase-3-vision-tria","status":"publish","type":"media_gallery","link":"https:\/\/touchoncology.com\/prostate-cancer\/conference-hub\/axel-merseburger-asco-2022-highlights-in-prostate-cancer-clinical-trials-phase-3-trial-of-shr3680-enzamet-trial-magnitude-trial-propel-trial-phase-2-lutetium-177-trial-and-phase-3-vision-tria\/","title":{"rendered":"Axel Merseburger, ASCO 2022: Highlights in prostate cancer clinical trials – Phase 3 SHR3680 trial, ENZAMET trial, MAGNITUDE trial, PROPEL trial, phase 2 lutetium 177 trial, VISION trial"},"content":{"rendered":"

ASCO 2022 showcased many important studies in prostate cancer. Prof. Axel Merseburger<\/strong> (Department of Urology, University of Lubeck, Germany), touchONCOLOGY’s Editor-in-Chief, joins us to share his highlights.<\/p>\n

In this interview he discusses: the phase 3 trial of SHR3680 versus bicalutamide in combination with androgen deprivation therapy in patients with prostate cancer (0:40); the interim overall survival results in ENZAMET (ANZUP 1304), an international, cooperative group trial of enzalutamide in metastatic hormone-sensitive prostate cancer (1:33); a study investigating ICE collaboration in clinical endpoints in rPFS and cPFS that appear to be valid surrogate endpoints for OS in prostate cancer (2:00); the first results of the phase 3 MAGNITUDE trial, and PROPEL trial (2:39), phase 2 lutetium 177 trial, and phase 3 VISION trial, targeted radioligand therapy with lutetium 177 vipivotide tetraxetan (3:20). Finally, he discusses a study around SUV mean that was shown to be strongly associated with overall survival in PSMA imaging in prostate cancer (4:41).<\/p>\n

ASCO 2022 Abstracts discussed in this interview:<\/strong><\/p>\n

    \n
  1. Abstract #5005: A phase 3 trial of SHR3680 versus bicalutamide in combination with androgen deprivation therapy (ADT) in patients with high-volume metastatic hormone-sensitive prostate cancer (mHSPC)<\/a><\/li>\n
  2. Abstract #LBA5004: Updated overall survival outcomes in ENZAMET (ANZUP 1304), an international, cooperative group trial of enzalutamide in metastatic hormone-sensitive prostate cancer (mHSPC)<\/a><\/li>\n
  3. Abstract #5006: Assessing intermediate clinical endpoints (ICE) as potential surrogates for overall survival (OS) in men with metastatic hormone-sensitive prostate cancer (mHSPC)<\/a><\/li>\n
  4. Abstract #12: Phase 3 MAGNITUDE study: First results of niraparib (NIRA) with abiraterone acetate and prednisone (AAP) as first-line therapy in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) with and without homologous recombination repair (HRR) gene alterations<\/a><\/li>\n
  5. \n
    \n

    Abstract #5001: Lu-PSMA-617 in PSMA-positive metastatic castration-resistant prostate cancer: Prior and concomitant treatment subgroup analyses of the VISION trial<\/a><\/p>\n<\/div>\n<\/li>\n<\/ol>\n

    Disclosures<\/strong>: Axel Merseburger has nothing to disclose in relation to this video interview.<\/p>\n

    Support<\/strong>: Interview and filming supported by Touch Medical Media. Interview conducted by Sophie Nickelson.<\/p>\n

    Filmed in coverage of the 2022 American Society of Clinical Oncology (ASCO<\/a>) annual meeting.<\/strong><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

    ASCO 2022 showcased many important studies in prostate cancer. Prof. Axel Merseburger (Department of Urology, University of Lubeck, Germany), touchONCOLOGY’s Editor-in-Chief, joins us to share his highlights. In this interview he discusses: the phase 3 trial of SHR3680 versus bicalutamide in combination with androgen deprivation therapy in patients with prostate cancer (0:40); the interim overall […]<\/p>\n","protected":false},"featured_media":50589,"template":"","class_list":["post-50588","media_gallery","type-media_gallery","status-publish","has-post-thumbnail","hentry","vocabulary_1-prostate-cancer","video_categories-asco-highlights"],"acf":[],"_links":{"self":[{"href":"https:\/\/touchoncology.com\/wp-json\/wp\/v2\/media_gallery\/50588","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/touchoncology.com\/wp-json\/wp\/v2\/media_gallery"}],"about":[{"href":"https:\/\/touchoncology.com\/wp-json\/wp\/v2\/types\/media_gallery"}],"version-history":[{"count":5,"href":"https:\/\/touchoncology.com\/wp-json\/wp\/v2\/media_gallery\/50588\/revisions"}],"predecessor-version":[{"id":50599,"href":"https:\/\/touchoncology.com\/wp-json\/wp\/v2\/media_gallery\/50588\/revisions\/50599"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/touchoncology.com\/wp-json\/wp\/v2\/media\/50589"}],"wp:attachment":[{"href":"https:\/\/touchoncology.com\/wp-json\/wp\/v2\/media?parent=50588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}