Search Results

Gastric and gastro-oesophageal junction (GOJ) adenocarcinomas are highly aggressive tumours with an overall poor prognosis, which is primarily attributable to the late stage of diagnosis resulting from nonspecific symptoms.1,2 While curative surgical resection is recommended for early-stage cases,3 advanced disease is treated with palliative intent, employing chemotherapy, immunotherapy and targeted therapies.4 The backbone of first-line treatment in […]

The I-SPY2 trial (NCT01042379) is a multicentre, phase 2 trial where patients with HER2-negative breast cancer were randomized to receive neoadjuvant cemiplimab plus REGN3767 and paclitaxel or weekly paclitaxel for 12 cycles. In this touchONCOLOGY interview, we speak with Prof. Claudine Isaacs (Georgetown University, Washington, DC, USA) who gives an overview of the I-SPY2 study […]

Esophageal cancer remains a devastating malignancy with an anticipated 15,850 deaths out of 17,290 new cases in the US in 2018.1 Forty percent of patients with esophageal cancer are diagnosed with metastatic disease and carry an even more dismal prognosis, with 5-year survival rates of <5%.1 The two predominant esophageal cancer histologic subtypes, comprising over […]

Urothelial carcinoma of the bladder (UCB) is a highly prevalent and lethal disease, with an estimated annual global incidence and mortality of 430,000 and 165,000, respectively.1The vast majority of mortality from UCB is due to invasive cancers (invading the muscularis propria and beyond, ≥T2) and advanced disease stages (lymph node or distant metastases, N1-3 and […]

The treatment of triple negative breast cancer (TNBC) is an unmet medical need, which refers to tumors that are estrogen receptor (ER) and progesterone receptor (PR) negative, and where human epidermal growth factor receptor 2 (HER2) is not overexpressed. This subset accounts for approximately 12–20 % of breast cancer patients.1 Gene expression analysis on this […]

The treatment of triple negative breast cancer (TNBC) is an unmet medical need, which refers to tumors that are estrogen receptor (ER) and progesterone receptor (PR) negative, and where human epidermal growth factor receptor 2 (HER2) is not overexpressed. This subset accounts for approximately 12–20 % of breast cancer patients.1 Gene expression analysis on this […]