Genitourinary Cancer, Prostate Cancer
Evaluating the Addition of Total Androgen Suppression to Radiation versus Radiation Alone for Locally Advanced Prostate Cancer
Andre Konski
Testosterone, the primary circulating androgen, is converted to its active form, alphadihydrotestosterone, by 5-alpha-reductase, and forms a complex with the dihydrotestosterone-binding domain of the androgen receptor. This complex then alters the structure of the DNA-binding domain allowing it to reversibly bind DNA sequences and androgen response elements in promoter or enhancer regions of androgenregulated genes. […]