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Trifluridine/tipiracil (FTD/TPI) is a novel oral formulation of two drugs with promising results in the treatment of metastatic colorectal cancer (mCRC).1 Trifluridine is a thymidine-based nucleoside analogue that, after intracellular phosphorylation, gets incorporated into DNA, causing DNA dysfunction.2 It was first identified by Callahan et al. in 1996 as an active impurity in the herbicide trifluralin, which […]

In our latest episode, we delve into the world of space medicine to explore how drug crystallization in microgravity could revolutionize biologic drug administration. Joining us is Dr Katie King, CEO of BioOrbit, to discuss the science, challenges, and technological advancements that could make space-based drug production a reality.

Domenica Lorusso, MD, PhD, is Director of Gynaecological Oncology Unit at Humanitas Hospital San Pio X, Milan, and Full Professor of Obstetrics and Gynaecology, Humanitas University, Rozzano, Milan. Prof. Lorusso has been involved in gynecological oncology research for more than 25 years and has conducted or participated in approximately 250 phase I-IV clinical trials in […]

Michael K Gibson, MD, PhD FACP, is Director of Translational Research for Esophago-Gastric Cancer (EGC) at the Vanderbilt-Ingram Cancer Center (VICC), where he also holds a faculty position as Associate Professor of Medicine. After receiving his medical degree from the Johns Hopkins University School of Medicine, Dr Gibson completed an Osler Medical Residency and medical […]

Providing valuable insights into the findings from key studies including DESTINY-Breast06 (NCT04494425), postMONARCH (NCT05169567), and TBCRC 048 (olaparib expanded) (NCT02032823), Dr. Tolaney explores the potential impact these results could have on clinical practice.

To further understand the key developments and research presented in the field of gynaecological oncology at ASCO 2024, we spoke with Dr. Domenica Lorusso, Professor of Obstetrics and Gynaecology at Humanitas University of Milan, Italy. In this interview, Dr. Lorusso discusses the findings from the BrUOG 354 (NCT03355976), AGO-OVAR 2.29/ENGOT-ov34 (NCT03353831), KEYVIBE-005 (NCT05007106), and CARACO (NCT01218490) trials, offering her valuable insights into the potential impact these results could have on clinical practice.

Endocrine therapy (ET) has changed the natural history of hormone receptor-positive (HR+) breast cancer (BC) and is the cornerstone of the treatment of HR+ BC. There are several ETs approved for the treatment of BC, including selective oestrogen receptor modulators (SERMs; tamoxifen), aromatase inhibitors (AIs; anastrazole, letrozole and exemestane) and selective oestrogen receptor degraders (SERDs; fulvestrant […]

Cholangiocarcinoma (CCA) is a cancer of the epithelial cells lining the biliary tree in the liver and can occur both inside the liver (intrahepatic CCA [iCCA]) and outside the liver (extrahepatic CCA, which includes both perihilar and distal cholangiocarcinoma) (Figure 1). Figure 1: A diagram showing the anatomical locations of the different subtypes of biliary tract […]

Outcomes for patients with metastatic colorectal cancer have steadily improve due to discovery of new drugs as well as increasing number patients undergoing local therapies.1 Angiogenesis is of a paramount importance in this disease and since vascular endothelial growth factor (VEGF) discovery several drugs targeting this pathway have been developed.2,3 Fruquintinib (HMPL-013) is a tyrosine kinase […]