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1013 Results Found for “clinical trials”
Choosing the appropriate adjuvant therapy in patients with melanoma undergoing neoadjuvant treatment
This article examines current evidence supporting the use of neoadjuvant immunotherapy in patients with resectable macroscopic stage III melanoma and critically discusses the selection of appropriate adjuvant therapy following surgery. It is written in the context of emerging evidence from ...
As EORTC enters a new chapter under the Presidency of Professor Benjamin Besse (Gustave Roussy Institute and Paris-Saclay University, Villejuif, France), the organization is looking to accelerate academic research while keeping patients and scientific independence at its core. In this detailed and in-depth Q&A, Prof Besse shares his priorities for EORTC, from supporting the next generation of investigators and broadening clinical trial populations, to giving greater weight to quality of life and patient perspectives. He also considers how emerging technologies, including artificial intelligence, could reshape the way cancer research is conducted.
The 2026 World Conference on Lung Cancer delivered several results with the potential to change clinical practice. My main takeaway was the speed at which effective options are multiplying in both small-cell lung cancer and molecularly defined non-small-cell lung cancer. The immediate advance is welcome, but it also makes treatment selection more complex: mature survival, intracranial control, toxicity, sequencing and access will increasingly matter as much as response rate or progression-free survival.
Circulating tumor DNA (ctDNA) has emerged as an innovative and minimally invasive tool in precision oncology. With a short half-life of 30–120 min, ctDNA provides real-time insight into tumor dynamics.1 In early-stage breast cancer, there is growing evidence supporting its potential ...
For almost two decades, R-CHOP has remained the established frontline standard for DLBCL, yet approximately 40% of patients are not cured with first-line therapy. At EHA 2026, Prof Georg Lenz presented new phase 3 data from the frontMIND study suggesting that this long-standing backbone may now be open to improvement. The study showed that adding tafasitamab and lenalidomide to R-CHOP significantly improved progression-free survival (PFS) in previously untreated patients with high-risk DLBCL and high-grade B-cell lymphoma (HGBL), marking one of the first positive frontline intensification trials in this setting in recent years.
Several important lymphoma studies presented at ASCO 2026 provided new data across newly diagnosed and relapsed/refractory disease settings. The studies spanned aggressive B-cell lymphomas and classic Hodgkin lymphoma, evaluating novel antibody-based combinations, epigenetic targeting strategies and chemotherapy-sparing approaches. Dr Tycel Phillips provides his expert insights into the six most important studies of the meeting.
Join us as leading experts discuss key data from the Plenary, Late-breaking and top oral sessions across each major disease area at ASCO 2026 touchONCOLOGY coverage of ASCO 2026 2026 American Society of Clinical Oncology (ASCO) Annual Meeting brought together the global oncology ...
At ASCO 2026 several neuro-oncology presentations focused less on introducing entirely new paradigms and more on defining where existing and emerging therapies may best fit. Across brain metastases and glioma, phase 3 data addressed longstanding practical questions around radiation delivery, chemotherapy duration, and local therapies, while updated targeted therapy data in IDH-mutant glioma continued to mature. In this piece, Dr Rimas Lukas highlights four main abstracts from ASCO 2026, discussing their take-aways and considering their potential relevance for clinical practice.
Congress coverage | This May, experts from around the world gathered in Glasgow, Scotland for the the 7th SIOP Europe Annual Meeting. This year celebrated the importance of collaboration, bringing together the diverse stakeholders involved in facing children and adolescents with cancer, and ensuring all voices were heard. The Annual Meeting was held in partnership with CCI Europe, ensuring the representation and participation of childhood cancer parents and survivors.
At the 7th SIOP Europe Annual Meeting, Anita Kienesberger (Chair, Childhood Cancer International Europe [CCI Europe]), discusses the evolving landscape of paediatric oncology advocacy. She shares insights on the critical importance of psychosocial support, the necessity of collaborative research and the ongoing challenge of health inequalities across Europe. As CCI Europe transitions into an independent legal entity, Anita Kienesberger highlights the organisation's strategic shift toward empowering survivors and standardising long-term care.
Professor Pamela Kearns discusses the key points from her Plenary presentation on how the ITCC is expanding access to innovative therapies, harnessing precision data and reshaping Europe’s paediatric oncology clinical trial landscape. “We want to bring innovation directly to ...
At the 7th SIOP Europe Annual Meeting, attention turned toward how children and families experience cancer treatment, not just how they respond clinically. One of the leading voices in this field is Professor Martha Grootenhuis (Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands). Her work focuses on integrating patient reported outcome measures (PROMS) into both clinical trials and routine care. In this Q&A, she discusses the key take-home messages from her Plenary session 'PROMS and feedback during trials: a new point at the horizon'.
Among the emerging voices at the 7th SIOP Europe Annual Meeting, was Dr Miguel Vieira-Martins, (Princess Máxima Center, Utrecht, Netherlands and member of Young SIOPE Steering Committee). He is deeply engaged in both the scientific and collaborative structures driving the field forward. In this interview, he discusses how opportunities in Young SIOPE are supporting early-career professionals, and reflects on the importance of international networks, the rise of immunotherapy and how meetings like SIOPE are accelerating progress from bench to bedside.
At the 7th SIOP Europe Annual Meeting, Professor Uta Dirksen (President, SIOP Europe) outlines a vision for a more equitable and collaborative future in paediatric oncology, one shaped as much by community engagement as by scientific innovation.
At SIOPE 2026, discussions around early phase clinical development highlighted both the scientific advances and structural challenges shaping modern paediatric oncology. Prof Cornelis Van Tilburg is closely involved in both areas through his leadership of the clinical trials unit and multiple investigator-initiated studies in paediatric neuro-oncology. In this interview, he discusses the barriers affecting European early phase research, evolving paediatric trial methodologies, and the importance of international collaboration in precision oncology.
Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality worldwide.1 Over the past two decades, the molecular characterization of NSCLC has transformed the therapeutic landscape by enabling the development of targeted therapies that have significantly improved outcomes ...
Among glial tumours of the central nervous system (CNS), one of the most devastating is the category of H3K27-altered midline gliomas because of their uniform and rapid mortality, high neurological symptom burden and predilection for paediatric, adolescent and ...
An immunosuppressed person is one whose immune function is impaired by underlying disease and/or immunosuppressive medications, resulting in reduced immunosurveillance against malignant cells and increased vulnerability to opportunistic infections. Longstanding immunosuppression has been linked to increased risk for cutaneous (...
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