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Lung cancer is the main cause of cancer deaths for both men and women in the US and worldwide. In the US, there were approximately 232,270 new cases diagnosed and 166,280 deaths due to this disease by the end of 2008.1 Non-small-cell cancer (NSCLC) accounts for approximately 80% of all cases of lung cancer, the […]

Malignancies of the lung are common, and are the leading cause of cancer deaths worldwide.1Non-small cell lung carcinoma constitutes the majority of these lesions, with small cell lung carcinomas comprising the remainder (15%).1Non-small cell lung cancers are subdivided into three histological subtypes: adenocarcinoma, large-cell carcinoma, and squamous-cell carcinoma.1The subtypes are associated with various mutations, and […]

Lung cancer is a major global health burden: it was responsible for 1.3 million deaths in 2004, equating to 2.3% of all deaths. Death rates from lung cancer are predicted to continue to rise, with the disease being responsible for 2.8% of all deaths (1.67 million) by 2015.1 Despite advances in treatment, survival rates from […]

Primary lung cancer is the most common cause of cancer-related death, causing 3 million deaths per year worldwide (World Health Organization [WHO] figures). Current incidence rates vary between 40 and 100 per 100,000 in Europe and 83 per 100,000 in the US.1 Since 1960, the rate of rise in lung cancer deaths in women has […]

Annually, 1.3 million cases of NSCLC occur.1 Despite smoking being the most important environmental causative factor for lung cancer, 10% of lung cancers occur in never-smokers, thus emphasizing the importance of genetic factors.2 Detection methods for genomic alterations include array-based profiling, targeted sequencing, and whole-genome sequencing. The following driver genetic alterations and respective frequencies occur […]

By way of orientation, I-ELCAP type screening is a clinical activity; a positive test CT initiates a process that leads to early diagnosis. Such diagnostic activity, as it is pursued in an individual, is squarely in the domain of clinicians. In this context, we suggest that it is the responsibility of the individual clinician to […]

This forms part of a larger epidemiological transition in which the burden of chronic, non-communicable disease is now increasing in less developed countries. Tobacco use is the single largest preventable cause of cancer in the world today. In addition to the accumulating risks associated with diet, alcohol and industrial exposure, the increase in tobacco use […]