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Few alliances have impacted patient care as significantly as the Myeloproliferative Neoplasms Research Consortium (MPN-RC). Established in 2006, the MPN-RC is an international group dedicated to advancing research and developing innovative treatment strategies for myeloproliferative neoplasms. In this episode, we speak with Prof. John Mascarenhas, about the coalition's founding, operational mechanics and how their efforts have led to paradigm-shifting therapies in the field.
Allogeneic haematopoietic cell transplantation (allo-HCT) has a bi-faceted role in the treatment of haematopoietic malignancies. First, allo-HCT gives high-dose chemotherapy a chance to reduce the leukaemic burden; second, it allows graft-originated natural killer and T cells to initiate an adoptive ...
COVID-19 has become one of the greatest challenges in medical history, and the rapid development and approval of effective and safe treatments is essential to minimise the loss of lives during the pandemic. Given the urgency of finding effective strategies, ...
Andrew I Schafer received his MD from the University of Pennsylvania, completed his internal medicine residency at the University of Chicago, and his fellowship in hematology at the Brigham and Women’s (formerly Peter Bent Brigham) Hospital. He rose to ...
Hodgkin lymphoma is a B-cell lymphoma that predominantly affects adults between 20–40 years of age, with a second incidence peak in those 55 years of age or older.1,2 It is also the most common form of lymphoma in adolescents, occurring in nearly ...
Polycythaemia vera (PV) is a chronic myeloproliferative neoplasm characterised by unregulated proliferation of red blood cells, and sometimes leukocytes and platelets in the absence of a recognisable physiological stimulus.1–4 Increased red blood cell mass leads to hyperviscosity of the blood ...
Janus kinase/signal transducer and activator of transcription inhibition A major breakthrough in understanding the molecular drivers of myeloproliferative neoplasms (MPNs) came in 2005, with the discovery of the Janus kinase 2 (JAK2) V617F driver mutation.1 Mutated JAK activates a number ...
Evolution of Knowledge in Essential Thrombocythaemia Disease Presented by: Gunnar Birgegård Division of Medical Sciences, Haematology, Uppsala University, Uppsala, Sweden Essential thrombocythaemia (ET) is a serious disease with significant morbidity and mortality and can sometimes transform to acute myeloid ...
Chronic myelogenous (or myeloid) leukemia (CML) is a myeloproliferative disorder characterized by increased and unregulated growth of granulocytes, leading to high white blood cell counts and splenomegaly. It was estimated that 5,430 adults in the US would be diagnosed with CML ...
Prognostic factors of clinical outcomes in patients with cancer are a useful tool in the practice of medicine, especially in the fields of oncology and malignant hematology. A good prognostic factor should reflect the biology of its targeted disease, be ...
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