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Human kidneys and bladder anatomical medical 3d render illustration
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Amena Ahmad, Oskar Lepiarczyk, Alison Birtle

Urothelial carcinoma (UC) is the 11th most common cancer in the UK, with approximately 11,000 new bladder cancer diagnoses annually.1 Globally, bladder cancer accounts for approximately 635,000 new diagnoses and 228,000 deaths annually, based on the latest GLOBOCAN estimates for 2024.2 Bladder cancer constitutes the vast majority of urothelial malignancies (90–95%), with upper tract urothelial […]

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Human kidneys and bladder anatomical medical 3d render illustration
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Amena Ahmad, Oskar Lepiarczyk, Alison Birtle

Urothelial carcinoma (UC) is the 11th most common cancer in the UK, with approximately 11,000 new bladder cancer diagnoses annually.1 Globally, bladder cancer accounts for approximately 635,000 new diagnoses and 228,000 deaths annually, based on the latest GLOBOCAN estimates for 2024.2 Bladder cancer constitutes ...

3D Rendered Medical Illustration of The Lungs.
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The 2026 World Conference on Lung Cancer delivered several results with the potential to change clinical practice. My main takeaway was the speed at which effective options are multiplying in both small-cell lung cancer and molecularly defined non-small-cell lung cancer. The immediate advance is welcome, but it also makes treatment selection more complex: mature survival, intracranial control, toxicity, sequencing and access will increasingly matter as much as response rate or progression-free survival.

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The plenary session at the AACR Annual Meeting 2026 brought sharp focus to one of oncology’s most urgent challenges: the global rise in early-onset cancers. Across four complementary presentations, speakers combined epidemiology, molecular biology and clinical insight to frame a multifactorial, and still evolving, picture of risk in younger populations. Below, we have broken down the key points and take-home messages from the session.

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In this Future Leaders interview, Dr Kevin Keane discusses the mentors who shaped his approach to clinically meaningful research, the integration of surgery and innovation in uro-oncology and the collaborative, patient-centred advances set to transform bladder cancer care.

Abstract Lungs with red human bronchial tree structure.
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Kübra Canaslan, Farheen Vhora, Fatemeh Ardeshir-Larijani

Early-onset lung cancer is typically defined as occurring in individuals aged 18–50 years, although there is no universally accepted definition.1–3 This entity, though rare, poses unique diagnostic and therapeutic challenges. This article synthesizes current evidence on the unique features and management ...

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Dr Darren Haywood, UTS cancer survivorship researcher and recipient of the 2025 MASCC Emerging Investigator Award, discusses the future of supportive oncology. He shares insights on survivorship care, cancer-related cognitive impairment, and why multidisciplinary collaboration is key to improving quality of life for people living with and beyond cancer.

3D medical animation of melanoma cancer cells
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João Felipe Lima Feldmann, Maria Amanda Londres Lopes Pinheiro, João Henrique Lima Feldmann

Liquid biopsy: Initial concepts and application in solid tumours The US National Cancer Institute defines liquid biopsy (LB) as ‘a test done on a sample of blood to look for cancer cells from a tumour that are circulating in the ...

Larry Holden, CEO GLI
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Liver cancer remains a significant global health challenge, often going undetected until it has progressed to advanced stages. A major barrier to early detection is the lack of awareness about liver health and risk factors, such as chronic liver diseases ...

Inflammation of the breast in women. Female breasts with signs of the disease. A low-poly construction of interconnected lines and points. Blue background.
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Mohammad Ammad Ud Din, Hania Liaqat, Ayesha Tayyab

The incidence rate of breast cancer (BC) is the highest in Pakistan among all Asian countries.1 In 2018 alone, 2.1 million cases were diagnosed, although the exact number is likely much higher due to poor reporting in rural areas and the lack ...

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To date, the cornerstone of curative treatment in early-stage gastrointestinal (GI) cancers includes surgery and sometimes radiation therapy. Depending on the stage and tumour type, these approaches are often combined with systemic neoadjuvant or adjuvant therapies. After all definitive therapy ...

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Glenn D Braunstein, Joshua J Ofman

Somatic DNA mutational analysis has transformed how we characterize existing cancer and select treatments. For example, circulating tumour cell-free DNA (cfDNA) can be used to select targeted therapies, monitor treatment response and detect disease recurrence.1 However, early attempts with targeted ...

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Reya Sharman, Rachna T Shroff

Pancreatic ductal adenocarcinoma (PDA) is predicted to beat colon cancer in terms of total cancer-related deaths in the USA by this year (2020).1 Given this projected burden of disease, efforts in understanding and developing new treatments for PDA are paramount. In ...

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“It is difficult to evaluate what did not happen.” – Academician, LV Gromashevsky The COVID-19 pandemic may be considered the first global health catastrophe in the past 100 years, since it has affected not only economic, political and medical paradigms, but also ...

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Craig E Devoe1 and Wadie F Bahou2 Northwell Health Cancer Institute, Zucker School of Medicine at Hofstra/Northwell, Lake Success, NY, USA Stony Brook University Medical Center, Stony Brook, NY, USA   Q. What is the current outlook on the effect ...

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Dr Shaila J Merchant, Julie La

Gastric cancer was the fifth most common cancer in 2018 with over one million new cases, 55% of which occurred in developed countries.1,2 Mortality remains high and gastric cancer is the third leading cause of cancer-related death in the world.1 Despite decreasing ...

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Biosimilars, which are copies of patent-expired large-molecule biologic drugs (Table 1),1–8 offer the same rationale as generic drugs. They can give patients, hospitals and healthcare systems the opportunity to expand patient access to care and offer potential budget savings to reinvest (...

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Breast cancer is the most commonly diagnosed cancer and is the second most common cause of cancer-related death among women in the US, leading to over 40,000 deaths annually.1,2 The cost of diagnosing, treating, and providing long-term follow-up care for these ...

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Thyroid cancer is the most common endocrine cancer, representing about 1 % of all malignancies diagnosed worldwide, with approximately 600,000 men and women alive in the US who have a history of cancer of the thyroid (http://seer.cancer.gov/statfa cts/html/...

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