Professor Nicolaus Kröger spoke to us at ASH 2018 about the major unmet needs in the treatment of myelodysplastic syndrome in elderly patients, and his phase III study comparing 5-azacytidine induction followed by allogeneic stem cell transplantation versus continuous 5-azacytidine according to donor availability in elderly patients with myelodysplastic syndrome.
Questions:
1. What are the major unmet needs in the treatment of myelodysplastic syndrome (MDS) in elderly patients? (0:10)
2. What is the rationale for induction therapy with 5-azacytidine prior to allogeneic hematopoietic stem cell transplantation (HSCT)? (0:58)
3. Could you tell us a little about the rationale for and design of the phase III study you are presenting at ASH? (2:08)
4. What were the findings of this study? (3:24)
5. What are the implications of these findings for the future treatment of elderly patients with MDS? (4:34)
Speaker disclosures: Nicolaus Kröger has nothing to declare in relation to this interview.
Filmed at the 60th American Society of Hematology (ASH) 2018 Annual Meeting, San Diego, CA, US, December 1–4, 2018.
