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We are delighted to present the latest edition of touchREVIEWS in Oncology & Haematology. This issue underscores the evolving landscape of cancer therapeutics, showcasing advances across a wide range of malignancies, from haematologic diseases to solid tumours, through novel mechanisms, emerging biomarkers and personalized treatment strategies. We begin with an editorial by Isabela Wen-Chi Chang […]

Austin Kulasekararaj, ASH 2018 – Treatments for Paroxysmal Nocturnal Hemoglobinuria

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Published Online: Dec 10th 2018

In this interview filmed at ASH 2018, Dr Austin Kulasekararaj discusses the phase III non-inferiority study investigating ravulizumab (ALXN1210) versus eculizumab in adult patients with paroxysmal nocturnal hemoglobinuria in patients currently treated with eculizumab. He then goes on to discuss how he thinks these findings will affect management strategies for patients with paroxysmal nocturnal hemoglobinuria in the future.

Questions:
1. What was the background and rationale behind the phase III non-inferiority study investigating ravulizumab (ALXN1210) versus eculizumab in adult patients with paroxysmal nocturnal hemoglobinuria currently treated with eculizumab? (0:10)
2. What were the key efficacy and safety findings? (1:51)
3. What are the next steps in this area of research over the coming years? (2:47)
4. How do you think these findings will contribute to management strategies for patients with paroxysmal nocturnal hemoglobinuria in the future? (3:38)
5. What other exciting developments have been presented at ASH 2018 for this indication? (4:28)

 

Speaker’s disclosures: Austin Kulasekararaj has participated in speaker’s bureau for Alexion, Celgene and Novartis, and received honoraria from Alexion, Amgen, Celgene, Novartis and Ra Pharma.

 

Filmed at the 60th American Society of Hematology (ASH) 2018 Annual Meeting, San Diego, CA, US, December 1–4, 2018.

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