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Gabriel Valagni, Nkafu Bechem Ndemazie, Tiago Biachi de Castria

Trifluridine/tipiracil (FTD/TPI) is a novel oral formulation of two drugs with promising results in the treatment of metastatic colorectal cancer (mCRC).1 Trifluridine is a thymidine-based nucleoside analogue that, after intracellular phosphorylation, gets incorporated into DNA, causing DNA dysfunction.2 It was first identified by Callahan et al. in 1996 as an active impurity in the herbicide trifluralin, which […]

John Mascarenhas, ASH 2019: Treating Myelodysplastic Syndromes and Myeloproliferative Neoplasms

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Published Online: Dec 18th 2019

At the 61st ASH Annual Meeting & Exposition, John Mascarenhas, Mount Sinai, discusses his presentation: Present Strategies and Future Directions: Treating MDS and MPN.

Questions

1. What are the major challenges in the treatment of patients with myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPNs)? (0:05)

2. What have been the most important recent advances in the treatment of MDS/MPN (first line and relapsed)? (1:10)

3. What factors should be considered when selecting the most appropriate treatment for an individual? (2:38)

4. What is the best treatment strategy for patients who experience symptomatic disease progression? (3:08)

5. How do you expect the treatment landscape to evolve in the coming years? (4:00)

 

John Mascarenhas has no conflicts of interest to declare in relation to this video.

Filmed at the 61st ASH Annual Meeting & Exposition 2019, Orlando, FL, USA.

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