An Introduction to Paediatric Oncology
Paediatric cancers are treated by a multidisciplinary team that includes paediatric oncologists, radiation oncologists, paediatric surgeons and specialist nurses. Significant treatment advances have been made over the past decade, including the introduction of targeted therapies such as TKIs and immunotherapies, which have dramatically improved patient outcomes across numerous cancer types.
Expert video highlights and insights from the conference hub and comprehensive peer-reviewed articles from our journal portfolio provide updates on the ever-changing landscape.
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Paediatric Oncology Content
Cornelis van Tilburg, ASCO 2019 – Larotrectinib in paediatric TRK fusion cancer
At the ASCO 2019 annual meeting, Cornelis van Tilburg discusses findings from recent studies investigating the efficacy and safety of larotrectinib in paediatric TRK fusion cancer patients (NCT02637687 and NCT02576431) and what this means for the future. Questions 1.What percentage of paediatric tumours have tropomyosin receptor kinase (TRK) fusions and in what tumour types are […]
Late Complications of Cancer in Childhood and Adolescence
Oncology & Hematology Review, 2013;9(1):52–9 DOI: https://doi.org/10.17925/OHR.2013.09.1.52
Since the 1960s, overall survival for all childhood cancers has substantially increased such that currently nearly 80 % of children will survive to five years following diagnosis, compared with 30 % 50 years ago. For most childhood cancers, survival at five years from therapy does not decrease significantly, and the vast majority of these children […]
Bronchial Carcinoid Tumours in Children – A Review
European Oncology & Haematology, 2011;7(3):196-9 DOI: https://doi.org/10.17925/EOH.2011.07.03.196
Carcinoid tumours are rare, malignant neuroendocrine neoplasms first described in 1888 in the ileum1 and called ‘Karzinoide’ by Oberndorfer in 1907.2 Neuroendocrine cells were originally called clear cells and later amine precursor uptake and decarboxylation (APUD) system cells.3 The term neuroendocrine was introduced with the finding that these cells are capable of producing bioactive amines […]
Challenges in Paediatric Oncology at the Onset of the 21st Century
European Oncological Disease, 2007;1(2):19-20 DOI: https://doi.org/10.17925/EOH.2007.0.2.19
Cancer is predominantly a disease of adults and the elderly. Fifty per cent of cancers occur after the age of 70 years, and 150,000 new cancers are diagnosed in France every year. Most adult cancers are slowgrowing adenocarcinomas. In contrast, childhood cancers (occurring before the age of 16 years) represent around 1% of all cancers, […]
Adolescent Psychopathology and Adult Health Behaviors in Long-term Survivors of Childhood Cancer
US Oncological Review, 2010;6(1):50-2 DOI: https://doi.org/10.17925/OHR.2010.06.0.50
Due to advances in medical treatment over the last few decades, rates of childhood cancer survivorship have reached almost 80%.1,2 The goal of treatment is to eliminate disease with the least compromise to subsequent health and quality of life.3 Approximately one in every 640 young adults between 20 and 39 years of age is a […]
Genome-wide Studies in Childhood Acute Lymphoblastic Leukemia
US Hematology, 2009;2(1):40-4 DOI: https://doi.org/10.17925/OHR.2009.02.0.40
The completion of the human genome project and additional ongoing efforts such as the international haplotype map (HapMap) project have promoted the exponential development of tools to investigate global genomic profiles at the DNA and transcript levels. Rapidly evolving technology now allows the interrogation of 1.8 million genetic markers (including almost one million single-nucleotide polymorphisms […]
The Epidemiology of Childhood Cancers
European Oncology, 2009;5(1):79-83 DOI: https://doi.org/10.17925/EOH.2009.05.1.79
In this article, the epidemiology and aetiology of childhood cancer are reviewed. The aetiology of childhood cancer is not clear. Both genetic predisposition and environmental agents are likely to be involved. There is a vast amount of literature on the subject, and PubMed (www.ncbi.nlm.nih.gov/PubMed) has been utilised to find key references. This review also synthesises […]
Pediatric Urologic Oncology
US Oncology Review, 2005;1(1):114-6 DOI: https://doi.org/10.17925/OHR.2006.00.00.1l
Wilms’ Tumor Wilms’ tumor is the most common pediatric urologic tumor—75% of patients present between one and five years of age, with an equal incidence between boys and girls. Patients present with an abdominal mass, which rarely crosses the midline. Contrast computed tomography (CT) of the chest, abdomen, and pelvis is obtained to evaluate both […]
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