Prostate Cancer

Immunotherapy in Advanced Prostate Cancer

European Oncology & Haematology. 2020;16(1):44–50

Prostate cancer is the second most common cause of cancer mortality in men, with most deaths occurring as a result of metastatic disease that has become resistant to androgen deprivation therapy (ADT).1 Most recently, immunotherapy, in the form of immune checkpoint inhibitors, has been successful in the treatment of a variety of advanced common solid tumours, […]

Treatment Sequencing of Abiraterone Acetate plus Prednisone and Enzalutamide in Patients with Metastatic Castration-resistant Prostate Cancer

European Oncology & Haematology. 2019;15(2):92–7

Prostate cancer is the most common cancer and the third leading cause of cancer-related death amongst men in Europe.1 Established treatment options for early-stage disease include surgery, radiation therapy and active surveillance,2 whereas patients presenting with advanced disease usually receive hormonal therapy using medical or surgical castration as the initial treatment.2,3 Unfortunately, most advanced prostate cancers acquire resistance […]

Julie Graff, ESMO 2019 – KEYNOTE-641 study in prostate cancer

We met with Julie Graff (Knight Cancer Institute) at ESMO 2019 to discuss unmet needs in the treatment of metastatic castration-resistant prostate cancer and KEYNOTE-641 (NCT03834493), a phase III study of pembrolizumab plus enzalutamide in this patient population. Questions 1.     What are the current unmet needs in the treatment of metastatic castration-resistant prostate cancer (mCRPC) […]

Axel Merseburger, ESMO 2019 – Advances in metastatic hormone-sensitive prostate cancer

Our Editor-in-Chief, Axel Merseberger (University Hospital Schleswig-Holstein), joined us at ESMO 2019 to discuss current limitations in the treatment of metastatic hormone-sensitive prostate cancer, use of antiandrogen agents, and what the future may hold. Questions 1.   What are the limitations of the current standard of care for metastatic hormone-sensitive prostate cancer (mHSPC)? (0:05) 2.   […]

Foreword – European Oncology & Haematology – Summer 2019

Welcome to the summer edition of European Oncology and Haematology. This issue features a wide variety of articles that illustrate the increasingly personalised, multidisciplinary approach to the management of cancer and haematological diseases. We begin with three expert interviews, which aim to give a snapshot of topical issues in haematology and haematological malignancies. Maria Domenica Cappellini […]

ESMO 2019, Barcelona Day 2 Highlights

ESMO 2019, Barcelona Day 1 Highlights

Targeted Alpha Therapy – Optimising Survival in Advanced Prostate Cancer

European Oncology & Haematology. 2018;14(Suppl 3);3–10

Targeted alpha therapy (TAT) is the delivery of high-energy alpha particles to cancer cells and the tumour microenvironment to treat cancer. After a survival benefit was shown for radium-223 versus standard of care in patients with metastatic castration-resistant prostate cancer (mCRPC), radium-223 became the first approved TAT.1–3 In the European Society for Medical Oncology (ESMO) […]

Proton Beam Therapy

European Oncology & Haematology, 2018;14(2):82–3 DOI: https://doi.org/10.17925/EOH.2018.14.2.82

Proton beam therapy is a type of radiotherapy that employs a high energy beam of protons rather than high energy X-rays to deliver a dose of radiotherapy for patients with cancer.1 The UK has been involved in the development of proton beam therapy; a specialist eye service at Clatterbridge, Merseyside, UK, was the first hospital-based […]