Percutaneous radiofrequency thermal ablation (RFTA) is a modality of therapy suitable in treating different kind of tumours and tumour like conditions. The effects are based on converting radiofrequency into heat, leading to necrosis of the target area. Today it is considered the treatment of choice for osteoid osteomas but it has also yielded satisfactory results in other kind of neoplasms, either benign or malign. This review includes some basic technical considerations of the procedure and describes its applications in treating bone and soft tissue tumours, as adjuvant therapy or as unique technique, with curative or palliative intention. These tumours include benign conditions (chondroblastoma, enchondroma, osteoblastoma, haemangioma, eosinophilic granuloma, aneurismal bone cyst, giant cell tumour, desmoid tumour) and malign ones, mainly soft tissue and bone metastases.
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