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Leukaemia

Charles De Bock, EHA 2019 – Safe Targeting of T-cell ALL by Gamma-secretase Inhibition

Published Online: June 27th 2019

We are joined by Charles De Bock, at EHA 2019 to discuss his presentation on safe targeting of T-cell acute lymphoblastic leukaemia by subunit selective gamma-secretase inhibition.

Questions
1. What is the rationale for the use of gamma‐secretase inhibitors for patients with T-cell acute lymphoblastic leukaemia? (0:05)
2. What are the limitations of current gamma‐secretase inhibitors? (0:45)
3. Could you tell us a little about your study investigating subunit specific gamma-secretase inhibition? (1:38)
4. What will be the next steps in this research? (3:10)

Charles de Bock has no conflicts of interest to declare in relation to this video.

Filmed at the European Hematology Association (EHA) 24th congress 2019, Amsterdam, Netherlands.

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