An Introduction to Leukaemia
Treating leukaemia holds numerous challenges, including the need for less toxic and more cost-effective treatments. Important additions to the landscape include targeted treatments such as FLT3 inhibitors, BCL-2 inhibitors and immune therapies such as monoclonal antibodies, antibody-drug conjugates and chimeric antigen receptor (CAR) T-cell therapies have been important additions to improve patient outcomes.
Expert video highlights, insights from the conference hub and comprehensive peer-reviewed articles from our journal portfolio provide updates on the changing treatment landscape. To learn more about how the latest developments impact on patient outcomes view our expert-led learning activities.
Role of New Immunophenotypic Markers on Prognostic and Overall Survival of Acute Lymphoblastic Leukaemia – A Systematic Review and Meta-analysis
European Oncology & Haematology. 2019;15(2):113–20
Acute lymphoblastic leukaemia (ALL) is a group of malignant haematological disorders characterised by accumulation of lymphoid cell precursors that replace normal bone marrow elements and inhibit the production of functional blood cells.1 ALL occurs in both children and adults, and more than one-half (56%) of those diagnosed are <20 years old, with chemotherapy required as standard […]
Massimo Breccia, ASH 2019: Discontinuing Tyrosine-kinase Inhibitors in patients with Chronic Myeloid Leukemia
At the 61st ASH Annual Meeting & Exposition, Massimo Breccia, Sapienza University of Rome, discusses discontinuing tyrosine-kinase inhibitors (TKIs) in patients with chronic myeloid leukemia. Questions 1. What is the rationale for discontinuing tyrosine-kinase inhibitors (TKIs) in patients with chronic myeloid leukemia (CML)? (0:05) 2. Following discontinuation of TKIs in patients with CML, when are […]
Naval Daver, ASH 2019: Venetoclax in Combination with Idasanutlin in Relapsed or Refractory AML
At the 61st ASH Annual Meeting & Exposition, Naval Daver, MD Anderson Cancer Center, discusses his presentation: Updated Results from the Venetoclax (Ven) in Combination with Idasanutlin (Idasa) Arm of a Phase 1b Trial in Elderly Patients (Pts) with Relapsed or Refractory (R/R) AML Ineligible for Cytotoxic Chemotherapy. Questions 1. What are the current therapeutic […]
Sabina Chiaretti, ASH 2019: Blinatumomab in Relapsed/Refractory Adult ALL
At the 61st ASH Annual Meeting & Exposition, Sabina Chiaretti, “Sapienza” University of Rome, discusses her presentation: Role of Blinatumomab in Minimal Residual Disease and Hematologic Relapsed/Refractory Adult Acute Lymphoblastic Leukemia Patients Treated over 5 Years. A Single Center Experience. Questions 1. What are the limitations of current therapeutic options for patients with relapsed/refractory acute […]
Paolo Ghia, EHA 2019 – ASCEND Phase III Study
We are joined by Paolo Ghia at EHA 2019 to discuss his presentation on ASCEND phase III study of acalabrutinib vs investigator’s choice of rituximab plus idelalisib (IDR) or bendamustine (BR) in patients with relapsed/refractory (R/R) chronic lymphocytic leukaemia (CLL). Questions What are the current treatment options for relapsed/refractory CLL and what are their […]
Alessandra Tedeschi, EHA 2019 – Ibrutinib for First-line Treatment of CLL
We are joined by Alessandra Tedeschi at EHA 2019 to discuss her presentation on the five-year follow-up of patients receiving ibrutinib for first-line treatment of chronic lymphocytic leukemia (CLL). Questions 1. How does ibrutinib fit into the treatment paradigm for chronic lymphocytic leukemia? (0:05) 2. What were the major findings of the long-term follow-up of […]
Othman Al-Sawaf, EHA, 2019 – Analysis of the CLL14 trial
We are joined by Othman Al-Sawaf at EHA 2019 to discuss his presentation on high efficacy of venetoclax plus obinutuzumab in patients with complex karyotype (CKT) and chronic lymphocytic leukemia (CLL): A prospective analysis from the CLL14 trial. Questions 1. Could you tell us a little about complex karyotype (CKT) in chronic lymphocytic leukemia (CLL) […]
Jorge E Cortes, EHA 2019 – Advances in the Treatment and Management of Acute Myeloid Leukaemia
Jorge E Cortes joins us at the EHA annual meeting in Amsterdam to discuss the most important advances in the treatment and management of acute myeloid leukaemia and provide an overview of promising emerging therapeutic targets. Questions 1. What have been the most important recent advances in the treatment of acute myeloid leukaemia (AML)? (0:05) […]
Petra Langerbeins PhD, EHA 2019 – Results of the Phase III Double-blind Randomised CLL12 Trial
We are joined by Petra Langerbeins at the EHA annual meeting in Amsterdam to discuss her presentation on ibrutinib versus placebo in patients with asymptomatic, treatment-naive early-stage chronic lymphocytic leukaemia (CLL): primary endpoint results of the phase III double-blind randomised CLL12 trial. Questions 1. What is the current treatment paradigm for patients with asymptomatic early-stage […]
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