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Endocrine therapy (ET) has changed the natural history of hormone receptor-positive (HR+) breast cancer (BC) and is the cornerstone of the treatment of HR+ BC. There are several ETs approved for the treatment of BC, including selective oestrogen receptor modulators (SERMs; tamoxifen), aromatase inhibitors (AIs; anastrazole, letrozole and exemestane) and selective oestrogen receptor degraders (SERDs; fulvestrant […]

James Brugarolas, ASCO 2019 – Advances in sarcomatoid RCC

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Published Online: Jun 11th 2019

At the ASCO 2019 annual meeting, James Brugarolas discusses sarcomatoid renal cell carcinoma, the current challenges and the advances that are defining a new treatment paradigm.

Questions

1. What is sarcomatoid renal cell carcinoma (RCC) and what is its prognosis? (0:04)
2. What are the major treatment challenges in sarcomatoid RCC? (0:54)
3. Why is sarcomatoid RCC particularly responsive to immune checkpoint blockade? (1:40)
4. What is the impact on patient survival? (2:45)
5. What further data are needed for checkpoint inhibitors to become the standard of care in sarcomatoid RCC? (3:11)

Speaker disclosure: James Brugarolas has nothing to disclosure in relation to this video interview.

Filmed at the American Society of Clinical Oncology (ASCO) 2019 Annual Meeting, Chicago, IL, USA.

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