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Amena Ahmad, Oskar Lepiarczyk, Alison Birtle

Urothelial carcinoma (UC) is the 11th most common cancer in the UK, with approximately 11,000 new bladder cancer diagnoses annually.1 Globally, bladder cancer accounts for approximately 635,000 new diagnoses and 228,000 deaths annually, based on the latest GLOBOCAN estimates for 2024.2 Bladder cancer constitutes the vast majority of urothelial malignancies (90–95%), with upper tract urothelial […]

James Brugarolas, ASCO 2019 – Advances in sarcomatoid RCC

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Published Online: Jun 11th 2019

At the ASCO 2019 annual meeting, James Brugarolas discusses sarcomatoid renal cell carcinoma, the current challenges and the advances that are defining a new treatment paradigm.

Questions

1. What is sarcomatoid renal cell carcinoma (RCC) and what is its prognosis? (0:04)
2. What are the major treatment challenges in sarcomatoid RCC? (0:54)
3. Why is sarcomatoid RCC particularly responsive to immune checkpoint blockade? (1:40)
4. What is the impact on patient survival? (2:45)
5. What further data are needed for checkpoint inhibitors to become the standard of care in sarcomatoid RCC? (3:11)

Speaker disclosure: James Brugarolas has nothing to disclosure in relation to this video interview.

Filmed at the American Society of Clinical Oncology (ASCO) 2019 Annual Meeting, Chicago, IL, USA.

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