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Circulating tumor DNA (ctDNA) has emerged as an innovative and minimally invasive tool in precision oncology. With a short half-life of 30–120 min, ctDNA provides real-time insight into tumor dynamics.1 In early-stage breast cancer, there is growing evidence supporting its potential for minimal residual disease (MRD) detection and recurrence monitoring. In metastatic breast cancer (MBC), ctDNA […]

Alona Zer, ASCO 2019 – Phase II study of nivolumab and ipilimumab in CKS

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Published Online: Jun 11th 2019

At the ASCO 2019 annual meeting, Alona Zer discusses the preliminary results from the interim analysis of a phase II study of nivolumab and ipilimumab in previously treated progressive Classic Kaposi Sarcoma (CKS) (NCT03219671).

Questions

1. Could you tell us a little about Classic Kaposi Sarcoma (CKS) and its prognosis? (0:04)
2. What is the rationale for using immune checkpoint inhibitors in patients with CKS? (0:35)
3. What are the limitations of current treatment options for CKS? (1:13)
4. What were the efficacy and safety findings of the phase II study investigating nivolumab and ipilimumab in patients with CKS? (1:50)
5. Which patients are most likely to respond to nivolumab plus ipilimumab? (02:37)

Speaker disclosure: Alona Zer has received a research grant and participated in an advisory board for BMS.

Filmed at the American Society of Clinical Oncology (ASCO) 2019 Annual Meeting, Chicago, IL, USA.

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