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Brian Van Tine, ESMO 2019 – Pazopanib in soft tissue sarcomas

Published Online: October 14th 2019

Brain Van Tine (Washington University in St Louis) joins us to discuss the results of the phase II study of pazopanib as front-line therapy in patients with non-resectable or metastatic soft tissue sarcomas who are not candidates for chemotherapy (NCT02300545).

Questions
1. What are the limitations of standard first-line chemotherapy in the treatment of soft tissue sarcomas? (0:05)
2. What is the rationale for the use of pazopanib as first-line therapy in patients with non-resectable or metastatic soft tissue sarcomas? (0:45)
3. Could you tell us a little about the phase II study of pazopanib and its efficacy and safety findings? (1:35)
4. Which patients are most likely to benefit from this treatment approach? (2:37)
5. How common is pazopanib resistance and how might this be overcome? (3:16)

Filmed at the European Society for Medical Oncology (ESMO) Congress 2019, Barcelona, Spain.

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