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    • Faculty & Disclosures
    Dr Kei Muro

    Aichi Cancer Center Hospital, Nagoya, Japan

    Dr Kei Muro, MD, PhD, is chief and director of the Department of Clinical Oncology and Outpatient Treatment Center at Aichi Cancer Center Hospital in Nagoya, Japan. read more

    He is an adjunct professor at Nagoya University Graduate School of Medicine and Tokyo University Graduate School of Medical Science, and is an adjunct and clinical professor at Nagoya City University Graduate School of Medical Science.

    Dr Muro graduated from the University of Tohoku Medical School in 1990 and completed his internal medicine training at the Iwaki Kyoritsu Hospital in 1993. He completed his residency in gastrointestinal oncology in the Digestive Endoscopy Division at the National Cancer Center Hospital East in 1997 and has been a staff doctor in the Gastrointestinal Oncology Division at the National Cancer Center Hospital since 1997. He was awarded his PhD in medical science from the Yokohama City University in 2021.

    Dr Muro is an executive board member of the Japanese Society of Medical Oncology and the Japanese Gastric Cancer Association. He is also a council member of the Japan Esophageal Society and the Japanese Cancer Association. He is a member of the American Society of Clinical Oncology and was a faculty member of the gastrointestinal tumours group at the European Society of Medical Oncology (2017–2021). He collaborates with the World Health Organization on the Japanese Gastric Cancer Committee. In terms of clinical trial activity, he is the chair of the gastrointestinal cancer group in the West Japan Oncology Group. He is also a reviewer for the Japanese Journal of Clinical Oncology and Esophagus. Furthermore, he was awarded the Nagoya International Cancer Treatment Symposium BMS Award in 2012 and was also awarded the Excellent Presentation Award from the Japan Society of Clinical Oncology in 2013. He is the author of more than 370 peer-reviewed publications.

    Dr Kei Muro discloses: Advisory board or panel fees from Amgen and AstraZeneca. Consultancy fees from Chugai and Ono. Grants/research support from Amgen, Astellas, Daiichi Sankyo, Eisai, Merck Serono, MSD, Novartis, Ono, Parexel International, Pfizer, Sanofi, Solasia Pharma and Taiho. Speaker’s bureau fees from Bristol Myers Squibb, Daiichi Sankyo, Eli Lilly, Ono and Taiho.
    Dr Rachel Riechelmann

    AC Camargo Cancer Center, São Paulo, Brazil

    Prof. Rachel Riechelmann, MD, PhD, is a medical oncologist and clinical scientist specializing in colorectal and anal cancers and neuroendocrine tumours (NET). She is currently the director of the Clinical Oncology Department at the AC Camargo Cancer Center in São Paulo, Brazil, and also serves as the president of the Brazilian Gastrointestinal Tumors Group (GTG). read more

    She has published more than 125 articles in peer-reviewed journals and is editor of Methods and Biostatistics in Oncology: Understanding Clinical Research as an Applied Tool (Springer, 2018). Prof. Riechelmann is a member of two European Society of Medical Oncology scientific committees (colorectal and NET), the Latin American Society of GI Oncology (SLAGO) and the European Society of Neuroendocrine Tumors Advisory Board, and the chair of the Gastrointestinal LACOG (Latin American Cooperative Oncology Group). She is also actively involved in mentoring and teaching of young oncologists.

    Dr Rachel Riechelmann discloses: Advisory board/panel fees from AstraZeneca and Servier (both relationships terminated). Grants/Research Support from Bayer and Libbs.
    Dr Chiara Cremolini

    University of Pisa, Pisa, Italy

    Dr Chiara Cremolini, MD, PhD,  is an associate professor in medical oncology at the University of Pisa in Italy. read more

    Following an MD Degree in 2008, a Master of Science in Clinical Trials, and a Specialty in Medical Oncology at the University of Pisa, she gained her PhD in Clinical Pathophysiology.

    She is mainly committed to the clinical management of patients affected by gastrointestinal malignancies, and is involved in clinical and translational research projects in the field of colorectal oncology. She is responsible for the scientific activities of the Clinical Trials’ Office at the oncology unit at Santa Chiara Hospital in Pisa. She actively contributes to clinical trials run by the Gruppo Oncologico del Nord Ovest (GONO), an Italian foundation involved in the design and execution of clinical and translational studies of several solid malignancies. Dr Cremolini served as the scientific secretary of GONO between 2015 and 2021, and has been the president since 2021. She is a faculty member of European Society for Medical Oncology gastrointestinal tumour group, and has been particularly involved in trials investigating intensified chemotherapy regimens as upfront treatment of metastatic colorectal cancer patients.

    With regard to translational activities, she is mainly interested in the identification of molecular predictors of benefit from systemic treatments, and to this purpose has collaborated with numerous international institutions. She is author of more than 200 papers in the field of colorectal cancer.

    Dr Chiara Cremolini discloses: Advisory board or panel fees from Amgen, Bayer, Merck, Pierre Fabre and Servier. Consultancy fees from Bayer. Grants/Research Support from Bayer, Merck and Servier.
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    • Gastrointestinal Cancers

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    An Introduction to Gastrointestinal Cancers

    Despite advances in radiotherapy, chemotherapy, and targeted therapy for gastrointestinal cancers, the disease has high recurrence rates and a poor prognosis. However, increased understanding of molecular biology has enabled significant progress in the management of oesophageal, gastric, liver, colorectal and pancreatic malignancies. Immunotherapies such as PD1 inhibitors plus HER-targeted therapies have improved survival in several gastrointestinal tumour types, while PARP inhibitors have been introduced as first-line maintenance treatment for BRCA-mutated metastatic pancreatic cancer.

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    Gastrointestinal Cancers Content

    Colorectal Cancer, Gastrointestinal Cancers
    Watch Time: 20 mins
    touchPANEL DISCUSSION
    Optimizing strategies for the treatment of colorectal cancer in the biomarker era
    CE/CME ACCREDITED Dr Kei Muro, Dr Chiara Cremolini, Dr Rachel Riechelmann Translations available:

    Dr Muro, Dr Cremolini and Dr Riechelmann discuss how biomarkers can guide treatment choices for patients with colorectal cancer.

    Learning objectives
    Learning Objectives
    • Choose appropriate first-line treatment for patients with CRC based on biomarker testing and clinical characteristics
    • Compare and contrast the available techniques for biomarker testing recommended for patients with CRC
    • Review the evidence for recent and emerging targeted therapy options for CRC
    Gastrointestinal Cancers
    Durvalumab: A PD-L1 Blocking Antibody for the Treatment of Adult Patients with Locally Advanced or Metastatic Biliary Tract Cancer
    Amit Mahipal, Mathias Palmer, Jennifer Gile

    touchREVIEWS in Oncology & Haematology. 2023;19(1):Online ahead of journal publication

    Biliary tract cancers (BTCs) are a heterogeneous group of adenocarcinomas that originate from the epithelial lining of the biliary tree and are classified into cholangiocarcinoma (CCA) and gallbladder cancer. BTC is an aggressive and rare epithelial malignancy that is usually diagnosed at an advanced stage with few effective therapeutic options.1 CCA is divided into extrahepatic and intrahepatic cholangiocarcinoma, with the extrahepatic […]

    Colorectal Cancer, Gastrointestinal Cancers
    Watch Time: 47 mins
    touchMDT
    How can HER2-targeted therapies be incorporated into the management of patients with CRC?
    CE/CME ACCREDITED Prof. Andrea Sartore-Bianchi, Dr Evgeny Yakirevich, Dr Kristen Ciombor, Dr Kelley Rone, Mr Scott Wilson

    Hear multidisciplinary team and patient perspectives on the management of HER2-positive colorectal cancer.

    Learning objectives
    Learning Objectives
    • Summarize how to test for HER2 amplifications in patients with CRC and how to interpret the results
    • Discuss how HER2-targeted agents can be incorporated into the management of patients with CRC
    • Outline how the multidisciplinary team can support patients with HER2+ CRC
    Colorectal Cancer, Gastrointestinal Cancers
    Watch Time: 34 mins
    touchPANEL DISCUSSION
    What are the implications of the latest data for HER2-targeted therapies in HER2-tested patients with colorectal cancer?
    CE/CME ACCREDITED Dr Ian Chau, Dr Antonia Sepulveda, Dr Silvia Marsoni

    Watch three experts discuss testing and treatment guidelines for HER2+ colorectal cancer (CRC) and clinical trial data for HER2-targeted therapies.

    Learning objectives
    Learning Objectives
    • Explain the testing methods used to identify patients with human epidermal growth factor receptor 2-positive (HER2+) colorectal cancer (CRC) and the interpretation of the results
    • Summarize the current guidelines for managing patients with HER2+ CRC
    • Discuss the recent efficacy and safety data for HER2-targeted agents in CRC
    Gastrointestinal Cancers, Immunotherapy
    Watch Time: 46 mins
    touchTALKS
    Emerging data with immunotherapy in esophageal squamous cell carcinoma and potential impact for clinical practice
    Dr Elizabeth Smyth

    Join Dr Elizabeth Smyth as she highlights the latest clinical data on the use of immunotherapy in the management of esophageal squamous cell carcinoma (ESCC).

    Learning objectives
    Learning Objectives
    • Describe the efficacy data for emerging treatments, including first- and second-line immunotherapy, for ESCC
    • Recall the safety data for emerging treatments for ESCC
    • Discuss how the latest data for emerging treatments for ESCC could impact clinical practice
    touchFEATURE
    Disease burden and unmet needs of patients with gastroenteropancreatic neuroendocrine tumours (GEP-NET)
    For HCPs in: Europe
    View Time: 8 mins Sponsored content

    Watch to learn more about the impact of GEP-NET on patients, and the need for earlier diagnosis.

     

    AAA-NP-GL-0248-22
    Date of Preparation: September 2022
    Gastrointestinal Cancers
    Developed by Touch
    Angela Lamarca, ESMO 2022: ABC-06 trial, quality of life results – Symptom-control with FOLFOX in the treatment of advanced biliary cancers
    Watch Time: 4 mins

    The ABC-06 clinical trial established active-symptom control + oxaliplatin/5-FU chemotherapy (FOLFOX) as the standard of care treatment after Cisplatin and Gemcitabine for advanced biliary cancers. Dr Angela Lamarca (Fundación Jiménez Diaz University Hospital, Madrid, Spain) joins touchONCOLOGY to discuss the efficacy and safety of second-line active- symptom-control with FOLFOX, and the quality of life and […]

    Gastrointestinal Cancers
    Developed by Touch
    Alvaro Arjona-Sanchez, ESMO 2022: HIPECT4 phase 3 trial investigating the efficacy and safety of adjuvant HIPEC in patients with locally advanced colon cancer
    Watch Time: 4 mins

    Peritoneal metastasis in locally advanced colon cancer has a poor prognosis from 3 years post surgical resection. Dr Alvaro Arjona-Sanchez (Institute of Biomedical Research IMIBIC, University Hospital Reina Sofia, Cordoba, Spain) joins touchONCOLOGY to discuss the HIPECT4 phase 3 trial investigating the efficacy and safety of adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with locally […]

    Gastrointestinal Cancers
    Developed by Touch
    Myriam Chalabi, ESMO 2022: Neoadjuvant immune checkpoint inhibition in locally advanced MMR-deficient colon cancer: the NICHE-2 study
    Watch Time: 7 mins

    Neoadjuvant immunotherapy has shown promising responses in several cancer types. In this touchONCOLOGY interview Dr Myriam Chalabi (Netherlands Cancer Institute, Amsterdam, Netherlands) discusses the NICHE-2 study results, investigating patients with non-metastatic deficient DNA mismatch repair (dMMR) colon cancer, treated with one dose of ipilimumab and two doses of nivolumab and underwent surgery ≤6 weeks of […]

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