An Introduction to Multiple Myeloma
Despite numerous advances in the last decade, multiple myeloma remains an incurable disease, characterised by relapses that ultimately result in uncontrolled disease and death. However, novel agents, such as proteasome inhibitors, immunomodulatory drugs and CD38-directed monoclonal antibodies, have substantially improved survival and tolerability. These emerging agents include immune checkpoint inhibitors and chimeric antigen receptor-engineered T-cell therapies, although eventual relapse remains an issue.
Expert video highlights and insights from the conference hub and comprehensive peer-reviewed articles from our journal portfolio provide updates on the ever-changing landscape.
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Multiple Myeloma Content
Improving outcomes in multiple myeloma with new treatment targets?
Watch a panel of experts discuss how novel targeted therapies are changing the treatment paradigm for multiple myeloma to achieve the best outcomes for patients.
- Recall the mechanisms of action and data for relapsed/refractory multiple myeloma treatments with novel agents
- Discuss the adverse event (AE) profiles of treatments with novel targets and how AEs could be managed in clinical practice
- Describe the possible role of agents with novel targets earlier in the multiple myeloma treatment pathway
Shaji Kumar, ASH 2020 – Highlights from ASH 2020
It was a pleasure to speak with our Editor-in-Chief, Shaji Kumar (Mayo Clinic, Rochester, MN, USA) to discuss the use of MEDI2228 (Clinical Trial Identifier: NCT03489525) and anti-BCMA CAR-T cells (Clinical Trial Identifier: NCT03915184) in the treatment of patients with relapsed/refractory multiple myeloma and to find out his personal highlights from this year’s congress. The […]
Latest Developments in Cellular Therapy for Multiple Myeloma
Oncology & Hematology Review (US). 2020;16(2):111-8 DOI: https://doi.org/10.17925/OHR.2021.16.2.111
Multiple myeloma (MM) is a malignant clonal disorder of plasma cells in the bone marrow, and more than 32,000 new cases are expected in the USA each year.1 Many clinical advances, including novel drugs and continuous therapy with treatment sequencing, have improved survival statistics.2 Despite this, MM remains largely incurable and the relapsed/refractory population remains vulnerable […]
Meletios-Athanasios Dimopoulos, ASH 2020 – Results from the Apollo Trial
We caught up with Meletios-Athanasios Dimopoulos (National and Kapodistrian University of Athens School of Medicine, Athens, Greece) to discuss his ASH 2020 presentation on the use of daratumumab in the treatment of relapsed/refractory multiple myeloma (Clinical Trial Identification: NCT03180736). The abstract ‘412 Apollo: Phase 3 Randomized Study of Subcutaneous Daratumumab Plus Pomalidomide and Dexamethasone (D-Pd) […]
Precision medicine in RRMM: Understanding how the data can be applied to practice
Watch a panel of experts discuss the latest advances in the treatment of relapsed and/or refractory multiple myeloma and the potential for precision medicine.
- Describe the current challenges in the treatment of multiple myeloma and considerations for overcoming poor prognosis
- Discuss the efficacy and safety data of novel agents being investigated in patients with RRMM
- Describe approaches to selecting treatment for patients with RRMM and the potential for precision medicine
Melflufen—A Novel Agent in the Treatment of Relapsed/Refractory Multiple Myeloma
Oncology & Hematology Review (US). 2020; 16(1):12–4 DOI: https://doi.org/10.17925/OHR.2020.16.1.12
Multiple myeloma (MM) is the second most common hematological malignancy after non-Hodgkin’s lymphoma.1 Although recent decades have seen considerable advances and improvements in clinical outcomes for patients with MM,2 MM remains incurable, with a high disease burden.3 Clonal evolution and genomic instability within myeloma clones inevitably lead to disease progression and treatment resistance.4 An increasing number […]
Current management of relapsed/refractory multiple myeloma and the future integration of BCMA-targeting agents
Watch a panel of internationally renowned experts discuss treatment options for patients with relapsed/refractory multiple myeloma, including how B-cell maturation antigen (BCMA)-targeted agents may be integrated into clinical practice.
- Discuss how treatment for patients with relapsed/refractory multiple myeloma can be selected based on disease- and patient-related factors
- Describe the rationale for B-cell maturation antigen (BCMA) as a treatment target and current agents in development
- Recall the latest data for BCMA-targeting agents in relapsed/refractory multiple myeloma and consider how they may be incorporated into clinical practice
BMCA-targeting agents in relapsed/refractory multiple myeloma: Distilling the data from the ASCO Annual Meeting 2020
Stay up to date with the latest developments in therapies targeting B-cell maturation antigen (BCMA) for the treatment of relapsed/refractory multiple myeloma with this expert summary from ASCO20 Virtual. Part 1: Watch internationally renowned expert Prof. Kwee Yong review key data from ASCO20 Virtual Part 2: Choose from leading experts who discuss what the data findings mean for global and regional practice
- Discuss the need for new treatment options for relapsed/refractory multiple myeloma and the rationale for targeting B-cell maturation antigen (BCMA)
- Describe the latest efficacy data for BCMA-targeting agents and evaluate how they may be integrated into the current treatment pathway
- Describe the latest safety data for BCMA-targeting agents and consider how adverse events could be managed in clinical practice
Biomarkers and novel therapies in relapsed/refractory multiple myeloma: Where are we heading in 2020?
Watch leading expert, Prof. Graham Jackson, discuss the importance of identifying high-risk patients with relapsed/refractory multiple myeloma and the role of biomarkers and novel therapies in optimizing individual patient care.
- Identify those patients with relapsed/refractory multiple myeloma with the most significant unmet needs
- Describe existing and novel biomarker testing and the relevance for optimizing the treatment of relapsed/refractory multiple myeloma
- Discuss the evidence for novel treatments and the potential for further treatment optimization with combination treatments in clinical trials and practice
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