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Radiotherapy

An Introduction to Radiotherapy

Radiation therapy is an important part of the therapeutic armamentarium for numerous solid tumours and metastases, with around 40% of cancer cures incorporating the use of radiotherapy. It is also effective for palliation and symptom control in patients with advanced or recurrent cancer. Hot topics include molecular radiotherapy, image-guided radiotherapy, intensity-modulated radiotherapy, stereotactic ablation therapy, adaptive radiation therapy, artificial intelligence and proton beam therapy. Finally, radiomics and radiogenomics are emerging as potential techniques for personalising radiotherapy.

Browse the content below where leading experts, discuss the latest data in video interviews and short articles from our conference hub and browse the selection of peer-reviewed articles from our journal portfolio.

Radiotherapy Content

Prostate Cancer, Radiology, Radiotherapy

Proton Beam Therapy

Jason Lester

European Oncology & Haematology, 2018;14(2):82–3 DOI: https://doi.org/10.17925/EOH.2018.14.2.82

Proton beam therapy is a type of radiotherapy that employs a high energy beam of protons rather than high energy X-rays to deliver a dose of radiotherapy for patients with cancer.1 The UK has been involved in the development of proton beam therapy; a specialist eye service at Clatterbridge, Merseyside, UK, was the first hospital-based […]

Head and Neck Cancer, Radiotherapy

To Hyperfractionate or not to Hyperfractionate – Is it Really a Question?

Jesper Grau Eriksen, Marco C Merlano

European Oncology & Haematology, 2016;12(1):19–20 DOI: https://doi.org/10.17925/EOH.2016.12.01.19

The term hyperfractionated radiotherapy (HFR) is used when radiotherapy is delivered in doses below 1.8-2.0 Gy per fraction. The rationale for doing so can be found in the differences in intrinsic radiosensitivity between tumours and late responding normal tissues. A small dose per fraction will tend to increase the therapeutic ratio between tumour and critical […]

Gastrointestinal Oncology, Radiotherapy

Future of Radiotherapy Delivery in Rectal Cancer— European and US Approaches

Jordan A Torok, Brian G Czito, Christopher G Willett

Oncology & Hematology Review, 2014;10(2):139–43 DOI: https://doi.org/10.17925/OHR.2014.10.2.139

Over the past several decades, two paradigms have emerged in the preoperative treatment of rectal cancer: a short course of radiation therapy (RT) often utilized in centers across Northern Europe and longcourse chemoradiation (CRT) in other parts of Europe and the US. The short-course technique was validated by randomized trials comparing this technique to surgery […]

Head and Neck Cancer, Radiotherapy, Supportive Cancer Care

Mucositis—Supportive Care During Radiotherapy or Chemoradiotherapy of Head and Neck Cancer

Eli Sapir, Avraham Eisbruch

Oncology & Hematology Review, 2015;11(1):50–2 DOI: https://doi.org/10.17925/OHR.2015.11.01.50

The majority of patients undergoing radiation therapy for head and neck (HN) cancer will develop oral mucositis, which is a clinical syndrome characterized by erythema, ulcerations, and odynophagia (see Table 1). It is almost universal and more severe among patients with oral cavity, oropharynx, and nasopharynx primaries.1–3 Although therapeutic ratio and outcomes are improved by […]

Head and Neck Cancer, Radiology, Radiotherapy

Head and Neck Cancer Highlights of ESMO Congress 2014

Panagiota Economopoulou, Giannis Kotsantis, George Kavourakis

European Oncology & Haematology, 2014;10(2):96–7 DOI: https://doi.org/10.17925/EOH.2014.10.2.96

Despite advances in multimodality treatment, the 5-year survival rate of patients with locally advanced head and neck squamous cell carcinoma (HNSCC) does not exceed 40–50% and survival rates for recurrent or metastatic disease (R/M) remain dismal.1,2 Low survival rates in combination with significant toxicities caused by current treatment strategies used in HNSCC emphasise the necessity […]

Head and Neck Cancer, Radiotherapy

Atlas-based Auto-contouring – Balancing Accuracy with Efficiency in OnQ rts®

Susan Barley, Clare Antoine, Gareth Webster

European Oncology & Haematology, 2014;10(2):98–101 DOI: https://doi.org/10.17925/EOH.2014.10.2.98

Delineation of contours remains the one part of radiotherapy that is completely manual in the majority of centres and therefore the potential for time-saving is huge,1 being estimated to range from 23 %2 to 41 %.3 One of the additional benefits of auto-contouring is the reduction in interobserver variation, which in general is not quantified […]

Colorectal Cancer, Gastrointestinal Oncology, Radiotherapy

Future of Radiotherapy Delivery in Rectal Cancer— European and US Approaches

Jordan A Torok, Brian G Czito, Christopher G Willett

Oncology & Hematology Review, 2014;10(2):139–43 DOI: https://doi.org/10.17925/OHR.2014.10.2.139

Colorectal Cancer, Gastrointestinal Oncology, Radiotherapy

How to Select for Preoperative Short-course Radiotherapy, While Considering Long-course Chemoradiotherapy or Immediate Surgery, and Who Benefits?

Rob Glynne-Jones, David Tan, Brendan J Moran

European Oncology & Haematology, 2014;10(1):17–24 DOI: https://doi.org/10.17925/EOH.2014.10.1.17

In patients with locally advanced rectal cancer (LARC), not involving the mesorectal fascia (MRF), surgery with total mesorectal excision (TME) is the standard of care. Prior to the TME era, high rates of local recurrence (LR) were observed after radical surgery, and 10–40 % of patients required a permanent stoma, even for tumours arising in […]

Genitourinary Cancers, Prostate Cancer, Radiotherapy

Combination of Hormone Therapy and Radiotherapy in Treatment of Locally Advanced Prostate Cancer—Recent Developments and Update

Roger YC Huang, Charles N Catton, Padraig R Warde

Oncology & Hematology Review, 2014;10(1):48–53 DOI: https://doi.org/10.17925/OHR.2014.10.1.48

Prostate cancer is the second most common cause of cancer and the sixth leading cause of cancer death among men worldwide with an estimated 899,000 new cases and 258,000 new deaths in 2008.1 Risk-stratification systems are used to assist with treatment selection, ensuring prognostic uniformity in clinical trials, and in the evaluation of treatment outcomes. […]

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Radiotherapy

An Introduction to Radiotherapy

Radiotherapy Content

Proton Beam Therapy

To Hyperfractionate or not to Hyperfractionate – Is it Really a Question?

Future of Radiotherapy Delivery in Rectal Cancer— European and US Approaches

Mucositis—Supportive Care During Radiotherapy or Chemoradiotherapy of Head and Neck Cancer

Head and Neck Cancer Highlights of ESMO Congress 2014

Atlas-based Auto-contouring – Balancing Accuracy with Efficiency in OnQ rts®

Future of Radiotherapy Delivery in Rectal Cancer— European and US Approaches

How to Select for Preoperative Short-course Radiotherapy, While Considering Long-course Chemoradiotherapy or Immediate Surgery, and Who Benefits?

Combination of Hormone Therapy and Radiotherapy in Treatment of Locally Advanced Prostate Cancer—Recent Developments and Update

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