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Rat sarcoma virus (RAS) proteins are a family of prototypical oncogenes frequently mutated in human cancers. Mutations in the RAS gene account for 19% of all pathogenic alterations and are the subject of extensive research in molecular and clinical oncology.1 The RAS family consists of three major isoforms, namely the Harvey rat sarcoma virus (HRAS), the neuroblastoma RAS […]

Niels Reinmuth, ELCC 2022: Characteristics of Long-term Survivors in the CASPIAN Study

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Published Online: May 5th 2022

The CASPIAN study evaluated the efficacy and safety of durvalumab plus tremelimumab and platinum-etoposide extensive-stage SCLC. touchONCOLOGY spoke to Niels Reinmuth (Munich, Germany) to discuss the characteristics of long-term survivors in the CASPIAN study.

Clinical Trial Identification: NCT03043872

Questions

  1.       What did the CASPIAN study teach us about the efficacy and safety of durvalumab plus tremelimumab and platinum-etoposide extensive-stage SCLC? 00:18-01:58
  2.       What was the rationale for your current analysis of CASPIAN data? 01:58-02:42
  3.       What were the findings of this study and what are their clinical implications? 02:42-03:03
  4.       What questions remain unanswered and what future studies are planned? 03:03-04:04

Speaker Disclosure: Niels Reinmuth is a Speaker’s Bureau participant with: Amgen, AstraZeneca, Bristol-Myers Squibb, Boehringer Ingelheim, Daiichi Sankyo, Hoffmann-La Roche, MSD, Merck, Pfizer, and Takeda.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Sophie Nickelson.

Filmed in coverage of the European Lung Cancer Congress 2022

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