Lung Cancer
Watch Time: 4 mins

Gerard Zalcman, ESMO 2022: IFCT-1701 phase III trial, investigating nivolumab plus ipilimumab in advanced non-small cell lung cancer

Published Online: September 14th 2022

First-line immunotherapy is a standard treatment for patients with advanced non-small cell lung cancer. Prof. Gerard Zalcman (Bichat Hospital, Assistance Publique-Hôpitaux de Paris; Institute of Cancer AP-HP Nord, Paris, France) joins touchONCOLOGY to discuss the IFCT-1701 phase III trial, investigating nivolumab plus ipilimumab, aiming to assess if 6-months nivolumab/ipilimumab duration was equivalent to continuation until progression in patients with disease control.

The abstract entitled ‘Nivolumab (Nivo) plus ipilimumab (Ipi) 6-months treatment versus continuation in patients with advanced non-small cell lung cancer (aNSCLC): Results of the randomized IFCT-1701 phase III trial‘ Abstract 972O, was presented at European Society for Medical Oncology (ESMO) 2022.

Questions:

  1. What is the basis of the standard 2 years duration of immunotherapy with advanced NSCLC and no targetable mutation? (0:21)
  2. What were the aims, design and eligibility criteria of your study? (0:50)
  3. What were the findings of the study in terms of disease progression? (2:04)
  4. What were the reasons for the premature halt of the trial? (2:44)
  5. What further investigation is planned? (3:02)

Disclosures: Gerard Zalcman receives grant/research support from Fondation ROCHE (France); is on the advisory board for BMS, Pfizer, Astra-Zeneca, Takeda, Inventiva, and PAredox therapeuticals; and receives honoraria/honorarium from BMS, Astra-Zeneca, and Pfizer.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Katey Gabrysch.

Filmed in coverage of ESMO 2022

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