Haematological Malignancies, Haematology
Iron Overload Screening and Diagnosis
Naomi Galili, Fahd Quddus, Azra Raza
Deposition of excess iron from multiple transfusions or increased absorption preferentially occurs in the liver, heart, pituitary, thyroid, pancreas, the gonads, and the skin. Saturation of transferrin receptors leaves non-transferrin-bound iron, which generates free radicals that harm membranes, proteins, and nucleic acids, resulting in tissue damage. This damage can be minimized or prevented through chelation; […]