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Highlights Immunotherapy, especially combinatory immunotherapy, has shown promise with prolonged survival for patients with advanced mesothelioma in the first-line setting (see the sections on ‘Systemic treatment and immunotherapy debut’ and ‘Randomized immunotherapy trials of mesothelioma’). Histology-based therapy is important to consider, with non-epithelioid subtypes responding better to immunotherapy than to chemotherapy (see the section on […]

Janine Simons, SABCS 2020 – Radioactive Iodine Seed Localisation in the Axilla with the Sentinel Node Procedure: The RISAS Trial

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Published Online: Dec 21st 2020

We had the pleasure to talk to Janine Simons (Erasmus University Medical Center, Rotterdam, Netherlands) about the RISAS study and its findings (Clinical Trial Identifier: NCT02800317). The abstract ‘Radioactive Iodine Seed placement in the Axilla with Sentinel lymph node biopsy after neoadjuvant chemotherapy in breast cancer: Results of the prospective multicenter RISAS trial‘ (ABSTRACT NUMBER: GS1-10) was presented at the virtual SABCS 2020, 8-11 December 2020.

Questions

  1. Could you tell us a little about radioactive iodine seed localisation and the history of its use to date in breast cancer therapy?
  2. What was the rationale for combining radioactive iodine seed localisation in the axilla with the sentinel node procedure (RISAS) for cancer staging after neoadjuvant chemotherapy?
  3. Could you give us an overview of the RISAS study and its findings?
  4. What are the implications of these findings for clinical practice?
  5. How do you expect the use of radioactive seed localisation to develop in the future?

Speaker Disclosures: Dr Janine Simons has nothing to disclose in relation to this video interview. Dr Janine Simons was previously at the Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands, where the RISAS study was conducted.

Support: Interview and filming supported by Touch Medical Media Ltd.

Filmed in coverage of the San Antonio Breast Cancer Symposium (SABCS) 2020.

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