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Highlights Immunotherapy, especially combinatory immunotherapy, has shown promise with prolonged survival for patients with advanced mesothelioma in the first-line setting (see the sections on ‘Systemic treatment and immunotherapy debut’ and ‘Randomized immunotherapy trials of mesothelioma’). Histology-based therapy is important to consider, with non-epithelioid subtypes responding better to immunotherapy than to chemotherapy (see the section on […]

Jason Luke, ESMO 2021: Efficacy and Safety Results from the KEYNOTE-716 Double-blind Phase III Trial

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Published Online: Oct 5th 2021

touchONCOLOGY joins Dr Jason Luke (UPMC Hillman Cancer Center, PA, USA) at ESMO 2021 to discuss the efficacy and safety results from the KEYNOTE-716 double-blind phase III trial.

Questions
1. Patients with high-risk stage II melanoma are at significant risk of recurrence after surgical resection – what treatment options do these patients currently have to prevent recurrence? (00:16-01:30)
2. What was the rationale for investigating pembrolizumab in patients with high-risk stage II melanoma, in terms of previously demonstrated efficacy? (01:30-02:22)
3. Please outline the key objectives and methodology of the KEYNOTE-716 trial? (02:22-03:00)
4. What were the main efficacy and safety findings of the KEYNOTE-716 trial? (03:00-04:17)
5. How will these results impact the treatment of patients with high-risk stage II melanoma? (04:17-04:47)

Disclosures: Jason Luke has no financial or non-financial conflicts of interest to declare in relation to this video.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Sophie Nickelson.

Filmed in coverage of the ESMO 2021 Annual Meeting.

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