Complete pathological response has been recognised as an important predictor of long-term remission, meaning it is often a key endpoint in clinical trials. Dr Bernardo Rapoport talks to touchONCOLOGY about complete pathological response and which clinical characteristics, such as molecular subtype and Ki-67, are associated with pathological response. Ki-67 is an important prognostic factor, not only in breast cancer but also in neoendocrine tumours, prostate cancer, and brain tumours. Dr Rapoport explains how the expression of Ki-67 translates to cell replication and how it can be an indicator of treatment response.
1. What is the definition of complete pathological response? (0:11)
2. Why has complete pathological response become such an important endpoint in trials of neoadjuvant chemotherapy in early breast cancer? (1:09)
3. What were the most important prognostic factors associated with complete pathological response in your recent study? (2:03)
4. What is the Ki-67 protein and what is its prognostic significance in early breast cancer subtypes? (3:09)
5. What future studies are planned in the investigation of this potential biomarker? (4:30)
Speaker disclosures: Bernardo Rapoport has nothing to disclose in relation to this interview.
Filmed at the European Society for Medical Oncology (ESMO) 2018 Congress, Munich, Germany, 19–23 October 2018.
Share this Video
Related Videos In Breast Cancer
Javier Cortés, ESMO 2021: Results of the Randomized Phase III DESTINY-Breast03 Study
touchONCOLOGY joins Dr Javier Cortés at ESMO 2021 to discuss the much-anticipated results of the randomized phase III DESTINY-Breast03 study. Questions 1. Why are antibody-drug conjugates needed in the treatment of HER2+ metastatic breast cancer? (00:17-01:17) 2. What were the objectives of the phase III DESTINY-Breast03 study? (01:17-01:55) 3. Could you tell us a little […]
Sara Tolaney, ASCO 2021: Abemaciclib in HR+, HER2+ high-risk early breast cancer
touchONCOLOGY joins Dr Sara Tolaney (Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA) at ASCO 2021 to discuss unmet needs and ongoing research in patients with early-stage HER2+ breast cancer. The abstract ‘eMonarcHER: A phase 3 study of abemaciclib plus standard adjuvant endocrine therapy in patients with HR+, HER2+, node-positive, high-risk early breast cancer […]
Sara Tolaney, St. Gallen International Breast Cancer Conference 2021: Patient-reported outcomes from MonarchE
Dr Sara Tolaney (Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA) joins touchONCOLOGY to discuss the patient-reported health-related quality-of-life outcomes data from the MonarchE trial (ClinicalTrials.gov Identifier: NCT03155997) in patients with HR+, HER2- breast cancer being treated with abemaciclib plus endocrine therapy. The e-poster ‘Patients’ quality of life and side effect perceptions in monarchE, […]
Journal articles and more to your inbox
Get the latest clinical insights from touchONCOLOGYSign me up!