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Bruton tyrosine kinase (BTK) plays a functional and integral role in B-cell receptor (BCR) signalling and is expressed in normal and malignant B cells. Given BTK’s central role in the survival and proliferation of malignant B cells, BTK inhibitors have been developed for use in various B-cell malignancies, with several US Food and Drug Administration approvals in […]

Javier Cortés, ESMO 2021: Results of the Randomized Phase III DESTINY-Breast03 Study

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Published Online: Oct 5th 2021

touchONCOLOGY joins Dr Javier Cortés at ESMO 2021 to discuss the much-anticipated results of the randomized phase III DESTINY-Breast03 study.

Questions
1. Why are antibody-drug conjugates needed in the treatment of HER2+ metastatic breast cancer? (00:17-01:17)
2. What were the objectives of the phase III DESTINY-Breast03 study? (01:17-01:55)
3. Could you tell us a little about the study, inclusion criteria, outcome measures and the impact on clinical practice? (01:55-04:58)
4. What is the potential for the use of trastuzumab deruxtecan in earlier treatment settings? (04:58-05:45)

Disclosures: Javier Cortes has no financial or non-financial conflicts of interest to declare in relation to this video.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Sophie Nickelson.

Filmed in coverage of the ESMO 2021 Annual Meeting.

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