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Bruton tyrosine kinase (BTK) plays a functional and integral role in B-cell receptor (BCR) signalling and is expressed in normal and malignant B cells. Given BTK’s central role in the survival and proliferation of malignant B cells, BTK inhibitors have been developed for use in various B-cell malignancies, with several US Food and Drug Administration approvals in […]

Ahmed Kaseb, ESMO 2019 – Nivolumab plus ipilimumab in HCC

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Published Online: Oct 3rd 2019

We joined Ahmed Kaseb (M.D. Anderson Cancer Center) at ESMO 2019 to discuss recent findings from the randomised, open-label, perioperative phase 2 study evaluating nivolumab alone versus nivolumab plus ipilimumab in patients with resectable hepatocellular carcinoma (NCT03222076).

Questions
1. What are the major unmet needs in the treatment of resectable hepatocellular carcinoma (HCC)? (00:02)
2. What is the rationale for the combined use of nivolumab plus ipilimumab in this treatment setting? (02:19)
3. What factors are associated with clinical response to nivolumab plus ipilimumab? (03:03)
4. How do you expect these findings to impact the standard of care for resectable HCC? (04:16)

Ahmed Kaseb has received research funding from BMS.

Filmed at the European Society for Medical Oncology (ESMO) Congress 2019, Barcelona, Spain.

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