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Gabriel Valagni, Nkafu Bechem Ndemazie, Tiago Biachi de Castria

Trifluridine/tipiracil (FTD/TPI) is a novel oral formulation of two drugs with promising results in the treatment of metastatic colorectal cancer (mCRC).1 Trifluridine is a thymidine-based nucleoside analogue that, after intracellular phosphorylation, gets incorporated into DNA, causing DNA dysfunction.2 It was first identified by Callahan et al. in 1996 as an active impurity in the herbicide trifluralin, which […]

Jean-Luc Van Laethem, ESMO 2021: Updated Results of the Phase II KEYNOTE-224 Study

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Published Online: Oct 5th 2021

touchONCOLOGY joins Professor Jean-Luc Van Laethem (Erasme University Hospital, Brussels, Belgium), principle investigator of the KEYNOTE-224 study, to discuss the updated results for pembrolizumab monotherapy as first-line therapy for advanced hepatocellular carcinoma.

Questions
1. What were the objectives of the KEYNOTE-224 study? (00:38-01:33)
2. What have previous study findings taught us about the clinical utility of pembrolizumab monotherapy as therapy for advanced hepatocellular carcinoma (HCC)? (01:33-02:52)
3. Could you give us an overview of the latest results from the KEYNOTE-244 study? (02:52-04:00)
4. Where do you place pembrolizumab in future treatment paradigms for HCC? (04:00-05:12)
5. How can outcomes with pembrolizumab in this indication be further improved and what future studies are planned? (05:12-06:03)

Disclosures: Jean-Luc Van Laethem has no financial or non-financial conflicts of interest to declare in relation to this video.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Sophie Nickelson.

Filmed in coverage of the ESMO 2021 Annual Meeting.

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