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Bruton tyrosine kinase (BTK) plays a functional and integral role in B-cell receptor (BCR) signalling and is expressed in normal and malignant B cells. Given BTK’s central role in the survival and proliferation of malignant B cells, BTK inhibitors have been developed for use in various B-cell malignancies, with several US Food and Drug Administration approvals in […]

John Marshall, ASCO GI22: Immune Checkpoint Inhibitors and Neoadjuvant Treatment Options for Oesophageal Cancer

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Published Online: Mar 8th 2022

touchONCOLOGY were thrilled to speak to Editorial Board member Professor John Marshall (Medstar Georgetown University Hospital, Washington, DC, USA) to summarise the latest developments and data from the ASCO Gastrointestinal Cancers Symposium 2022.

The phase III CheckMate 577 Study (NCT03044613): https://meetings.asco.org/abstracts-presentations/204867

KEYNOTE-062 (NCT02494583): https://meetings.asco.org/abstracts-presentations/204515

JCOG NExT study (UMIN000014795): https://meetings.asco.org/abstracts-presentations/204882

Questions:

  1. What have recent clinical study data taught us about the optimal front-line use of immune checkpoint inhibitors in advanced gastro-oesophageal cancer? 00:16-02:50
  2. Could you tell us a little about the JCOG NExT study and its implications for the future neoadjuvant treatment for locally advanced esophageal cancer? 02:50-05:21

Speaker Disclosure: John Marshall has no conflicts of interest to declare in relation to this video.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Sophie Nickelson.

Filmed in coverage of the ASCO Gastrointestinal Cancers Symposium 2022.

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