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Rat sarcoma virus (RAS) proteins are a family of prototypical oncogenes frequently mutated in human cancers. Mutations in the RAS gene account for 19% of all pathogenic alterations and are the subject of extensive research in molecular and clinical oncology.1 The RAS family consists of three major isoforms, namely the Harvey rat sarcoma virus (HRAS), the neuroblastoma RAS […]

Agne Paner, ASH 2019: New Approaches in the Treatment of Relapsed/Refractory Plasma Cell Dyscrasias

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Published Online: Dec 18th 2019

At the 61st ASH Annual Meeting & Exposition, Agne Paner, Rush University Medical Center, discusses her presentation: Myeloma: Therapy, excluding Transplantation: New Approaches in the Treatment of Relapsed/Refractory Plasma Cell Dyscrasias.

Questions

1. What are the major unmet needs in the treatment of relapsed/refractory multiple myeloma? (0:05)

2. What were the findings of the HORIZON study? (0:28)

3. What progress has been made in identifying biomarkers of response to Melflufen plus Dexamethasone in relapsed/refractory multiple myeloma? (1:37)

4. What combination therapies are being investigated for relapsed/refractory multiple myeloma? (1:53)

5. How does this treatment differ from other treatment options? (2:42)

 

Agne Paner has received consulting honoraria for advisory board from Oncopeptides.

Filmed at the 61st ASH Annual Meeting & Exposition 2019, Orlando, FL, USA.

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