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Allan A Lima Pereira, Gabriel Lenz, Tiago Biachi de Castria

Despite being considered a rare type of malignancy, constituting only 3% of all gastrointestinal cancers, the incidence of biliary tract cancers (BTCs) has been increasing worldwide in recent years, with about 20,000 new cases annually only in the USA.1–3 These cancers arise from the biliary epithelium of the small ducts in the periphery of the liver […]

Bernd Jilma, ASH 2022: The pathophysiology and unmet treatment needs in cold agglutinin disease

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Published Online: Jan 11th 2023

Cold agglutinin disease (CAD) is a rare, autoimmune, clonal B cell disorder. In this touchONCOLOGY interview, we speak with Dr Bernd Jilma (Medical University of Vienna, Vienna, Austria) to discuss the pathophysiology of CAD and the unmet treatment needs in this disease.

The abstract entitled ‘Trial in Progress: Randomized, Double-Blind, Placebo-Controlled Multicenter Phase 3 Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Patients with Cold Agglutinin Disease (CASCADE)’ (Abstract #2333)  was presented at ASH Annual Meeting, 10–13, December, 2022.

Question:

Could you tell us a little about cold agglutinin disease (CAD), its pathophysiology and the unmet needs in its treatment? (0:17)

Disclosures: Bernd Jilma is on the advisory board, speaker’s bureau and a consultant for Sanofi as well as having received grant/research support and honoraria from Sanofi. 

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Danielle Crosby.

Filmed as a highlight of ASH 2022

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